Genomic Feature
hza7
- ID
- ZDB-ALT-210504-1
- Name
- hza7
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Jing-Xia Liu Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 6: 10094207 - 10094211 (GRCz11) (1) Details
- Nucleotide change
- ACAGA/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 5 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
GTGTTCATACTTCAATACTGTCAGCTTTGCTGTGGAGAGCTATTCGGTTTGTTCAGAACTGATTTACAACCTTTATTTGTGTTAGTTTTGCACTCGATGACATAAATCAGTTTAATCATTGACAGAAAATGTACGAGCAAAAGTTTGCCCGGCGGTGACGTGTGCAAACTCAACCGGGGCAGATGATCGTGAAGACACGCGGAGCGCAAAACCTGCGGGGATTTAAACGCGCGCGCACCATCACGCCACAGGACGGCACAGACATGTCACACACCTGAGACTCCTGCTTTGCAATTGTTTGTTAACGAAAGGTAATCTAAACTCCGGTCTTAGGTCTTCTGGGACACCGGCACAATGAATAAACTCAGTCCTTTCAGTAATCTTGCCAAGTTTATCTCCAAGTCGCCTGATAATGGGCCAGTCGGCGGAGAGCAGCTCTGCATGAAGGACTGCAAACCCCTGTGCCACTGCGACCCGGAGCTCTGCGTTTGCTCTTTACC
ACAGA/- ATAGTAAAGATGGACCCACGGAATATAAGGTCAGTTTCTATTATTACAGTTAGGATAGCAAACACGTTTAAAATGAGGGAAAACTGCGTTTAAAAATTTCCAGAATGATACCTAAATATTTTCTACAAAAGTTGTAGACCTATCTGAAGCCTAATTGTAAAATAACAGTACACAGTGGTACACTCAGAAAAGAAGGTTTAAGGTACAAAATCTGTCAGTGGGCTGGCTTTTCAAAAGATACACGTTATCTAAAGAGACCTACAATTACATTTTAGTAAGGAAATTCTAGATTTTCACAACGTTACTCTAATTTTTCACAGTAAATTACATTAGTATCACTTTACAGCATTTAACAAATATTCAAAGTAATGTTTTGTATTCAGATTTTTACATGATTACTGTAAAAAGGGCTTTATCTTTTACATGTTAGTTAAAGGAAATTAAACAGTTTTTATTTCATTCAACATAAACATTAATACAAATGAACTTTTATGTCAGTA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| atp7bhza7/hza7 | Homozygous | ♀+/- ♂+/- | Fig. 7 from Zhang et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Li, L., Tai, Z., Liu, W., Luo, Y., Wu, Y., Lin, S., Liu, M., Gao, B., Liu, J.X. (2023) Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis. iScience. 26:106406106406
- Wu, Y., Liu, W., Li, L., Tai, Z., Gao, B., Liu, J.X. (2023) Atp7b deficiency induces zebrafish eye developmental defects. Metallomics : integrated biometal science. 15(5):
- Li, C., Wu, Y., Li, H., Wang, H., Liu, J.X. (2022) Lipid-related metabolism during zebrafish embryogenesis under unbalanced copper homeostasis. Fish physiology and biochemistry. 48(6):1571-1586
- Jin, X., Liu, W., Miao, J., Tai, Z., Li, L., Guan, P., Liu, J.X. (2021) Copper ions impair zebrafish skeletal myofibrillogenesis via epigenetic regulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21686
- Zhang, T., Guan, P., Liu, W., Zhao, G., Fang, Y., Fu, H., Gui, J.F., Li, G., Liu, J.X. (2020) Copper Stress Induces Zebrafish Central Neural System Myelin Defects via WNT/NOTCH-hoxb5b Signaling and pou3f1/fam168a/fam168b DNA Methylation. Biochimica et biophysica acta. Gene regulatory mechanisms. 1863(10):194612
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