Genomic Feature
vc60
- ID
- ZDB-ALT-210311-10
- Name
- vc60
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Lister Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 4: 6044397 - 6044409 (GRCz11) (1) Details
- Nucleotide change
- TCCTCAAGGCCTC/CT
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 2 bp inserted / 13 bp deleted in Exon 7 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
AATTGAACTTTTTATCGAATTTAAATGGAAGGCGAGTGCTGTCACCTCGCCATTAACACAAGATAAAGGAGATTATTAGCCGCGATCAGGCCAACATCTTATTCCAAAGAAAGAGACAATTTCACGACACTTTCCTCCTTTTAAAAAGTAATGGTATCGGGAATGACTGCACTTTACTTCAGCTTCCGAACTTCTTTTTTTTTTTTCCCCGACACCTATTTTTGCTCGGGGATTAATTTTACCATACAAGAGGCTGCAGAATGGTCTTTCTTGCAGACGTACTTAACTATTCCATTAAAATTCCCATTCAAAGGCAAGGTAATGTCCGAGAATGAATAATTGGCCATGTAAATCACAGAGGAGAGAGAGAGAGGAAAAAAAGGAGACCCTTGTGAGGCTTTTCTCTGTGTATGAAAGTTCTGCTGATGCGAAGGCGCTGTTGAGAAAGGTTATCTTTTACGTTTTTTCTGGCAGTGATATGCGCTGGAACAAAGGGACGA
TCCTCAAGGCCTC/CT GGTGGAATACATTAAGTGGCTGCAGAAAGAGCAGCAACACGCTCGTGATCTGGAGAGCCGACAGAAGAAACTTGAGCAGGCCAACAGAAGACTCCAGCTACGGATCCAGGTAAAGAGACTGAGAACAAGAGGAAAACTGTCATGAGAGAGAGAGAGAGACATGGCAGACAGCCAGGGTTGGAGGAGTCAAAGACCAAAGGCAAAGAGAGATGTGAAAAAACTGAAGGATTTAATGCTGAACAAAAGAAGAGTTAGGGTCAACGTAGCTTTTAAAAAGTGGAAAATATACTTTAAGGCTACTTATCTTTACTGCTATAACTATCAGATGATGTTCAGTTTGCTAAATTGATAGCAATAAAAGGATCATTTACTCATTATTTACACATACTGAAGTGGTTTCAAACCTTTAGGAGTTTCTTTTTAAATGTTGAGCACTAAAGAGGATATTTTGAAGAAGGATGAAAACGTGTCGCTATTGACTTTCATAGTAGAAATAAAAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| tfecvc60/vc60 | Homozygous | ♀+/- ♂+/- | 3 figures  from 2 publications | 2 figures from Petratou et al., 2021 | |
| tfecvc60/+ | Heterozygous | ♀+/- ♂+/- | |||
| foxd3zdf10/zdf10; tfecvc60/vc60 | Complex | Fig 7 from Petratou et al., 2021 | |||
| mitfaw2/w2; tfecvc60/+ | Complex | Fig. 1 from Sinagoga et al., 2020 | |||
| mitfaw2/w2; tfecvc60/+ | Complex | Fig. 2 from Sinagoga et al., 2020 | |||
| mitfaw2/w2; tfecvc60/vc60 | Complex | 2 figures from Sinagoga et al., 2020 | |||
| mitfaw2/w2; tfecvc60/vc60 | Complex | Fig. 1 from Sinagoga et al., 2020 | |||
| mitfaw2/w2; tfecvc60/vc60; w47Tg | Complex | ||||
| mitfaw2/w2; tfecvc60/vc60; w47Tg | Complex | Fig. 2 from Sinagoga et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Petratou, K., Spencer, S.A., Kelsh, R.N., Lister, J.A. (2021) The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor. PLoS One. 16:e0244794
- Sinagoga, K.L., Larimer-Picciani, A.M., George, S.M., Spencer, S.A., Lister, J.A., Gross, J.M. (2020) Mitf-family transcription factor function is required within cranial neural crest cells to promote choroid fissure closure. Development (Cambridge, England). 147(21):
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