Genomic Feature
mi604
- ID
- ZDB-ALT-200325-2
- Name
- mi604
- Synonyms
-
- D8 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Cunming Duan Lab
- Current Source
- Other Pages
Notes
| Comment | Citation |
|---|---|
| Trpv6 mutant protein lacks the six transmembrane domains and the critical ion ... | Xin et al., 2019 |
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 16: 12312277 - 12312284 (GRCz11) (1) Details
- Nucleotide change
- GCTCCGGG/-
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 8 bp deleted (1)
- Transcript Consequence
- Frameshift (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
CCTTACAAACTCCACTTAACCCACCTTTAAATCCACCAATTCCAGTAAACCACTGGTTGCTAAACGTAACAGTATCCCACTTCAACAACATTTTGCAATACAACATGACCACAATATGGACATTATACCTAACAATTATTCTTTATTCCATGCATGTACCATATAGTAGCTAACAGAGTGTGACCATACGAACAATAGCTAAAAATGATTACCACAATAGAAGCATATGTCTCACCATAGTAAAACAGGCCTTCTCTTCTTTTGCGGAAGTACATGCCTGTGACTCTGGGTGTCGTCACATCAGCTCCTCTTTTTATCATCTCCCAGATTAAGTTAGGATTCTGATTAATCACAGCGATGTGAAGGGCTGTTAAACCTGTCAATCAGAGCACACTTGCTTAAGATTTTACAGTGTGAACAGTCATATTTAATTGTTTGAGGAAGTGTCTGTTTCTAATAATGACCATGGTAGAGTTCAGATGTCATGGGCTCGTTGATGA
GCTCCGGG/- GCTCCATTCATTAAAGCCACCGCTGCTTCAAAGTTATCATTCATCACAGCAACATGCAGAGCTGTCTCTCCAAGCTCACCTGCAACAAACACACACAATGTCAGAGACACATTTACAATCTGTATTTATCATTCAGTGCATTGTTAGATATTAAGACATTAAAGCAACGTTCTGTCATGAAACCGCCATGAAACGAAGGCTGTAAGTCCTATCCAGTTTGCTTCTAACCATATTGTTAAATAAGGCGCAGGTGAGCAGCCAATGGGCTTGCTTCTCAATATTTAAATATCTTGTATTATTTGGAATAGCAATCTACAGTACGTTTTTGGGATAGCTGTCTGAAAATTAAGTTAAAATAAGTGAAGATAATCCCTAAATTTAATCCTTTTGCTGATCTGCTCACTGTTTTAAGTAAGCACTCATACATTTAAATTCAGGCTCCATGTTTACAAGTTTCAGACTGATCTCACGAGGAAACGTAAGTATTTTACGTTTTGTCA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| trpv6mi604/mi604; mi602Tg | Complex | 4 figures  from Xin et al., 2019 | Figure 2 from Xin et al., 2019 | ||
| trpv6mi604/+; mi602Tg | Complex | Figure 2 from Xin et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Li, S., Li, H., Wang, Z., Duan, C. (2023) Stanniocalcin 1a regulates organismal calcium balance and survival by suppressing Trpv6 expression and inhibiting IGF signaling in zebrafish. Frontiers in endocrinology. 14:12763481276348
- Li, Y., Liu, C., Rolling, L., Sikora, V., Chen, Z., Gurwin, J., Barabell, C., Lin, J., Duan, C. (2023) ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal. Proceedings of the National Academy of Sciences of the United States of America. 120:e2216310120e2216310120
- Xin, Y., Malick, A., Hu, M., Liu, C., Batah, H., Xu, H., Duan, C. (2019) Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6. eLIFE. 8:
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