Genomic Feature
f234jy
Notes
No data available
Variants
- Variant Type
- Insertion
- Variant Location
- Chr 7: 33113996 - 33113997 (GRCz11) (1) Details
- Nucleotide change
- -/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 1 bp inserted in Exon 2 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CATCATGGCAAAGATAAAATAAATCAGTTATTAGAGATGAGTTATTAAAACTATTATGTACGTTAGAAATGTGTTGAAAAAATTTGCTCTCCGTTAAACAGAAATTGGGGAAATAAACAGGGGTGCTAATAAGTCTGACTTCAAACTGTATGTATGTACGATTGTACGATAGATAGTACGATAGATGGATAGTACAATAAATAGATGGATGGATGGATGGATGCATGGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGAAATAACATTTATCTACCTGAAATAGTTTTAATGCCTTGACAAGTCCTCCGACTTCATTCTTCAGAGAGAAGACAATCGCGGCATGTTCCCTCTTGGAGGAAAGTTTCTTG
-/T TCTTTGTTCTCGTCAGTCTTATGGAAAGTAGTTTTTCTCAGCTTCATAAAAAAAGACAGGTTGTATTGAAGGTCGTTGGGTAATACTCGGGTGTTTGTTCACATTAGCATGACAATCTCTACTACAGCAGATGTGTAATATCCTGAGTGACTGAACTTCTGTTTGTTTTTGACCTGCATTTTAAACAGGAAATCGTTTTTCACATGCAAATATTTATAGTTTCTAACTGTCAAAAGACTGGGTAGGATGAATAAATTGTTTAATGAATTAACATTTTGAATAATTATTTTTAAGGAATTTGTAGCGACGTCAATGCGATGTAAAACCTAACGACAAGTGCCAAAAAATAATCATTTTATTAATTAAAAATATACAAGGCATAACTTGATAAACCTTCCATGAATACGTAAAAATTGATGAATAAAACTTTTAAAAGACCATTTGTAACATACATTACATATATAAGTAATTTACATACATAATAGTCCTGTATTGTGTGTC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| tph1bf234jy/f234jy | Homozygous | ♀+/- ♂+/- | 3 figures from 2 publications | Fig. 3 from Pan et al., 2020 | |
| tph1bf234jy/f234jy + MO2-tph1b | Complex | ||||
| tph1aot203/ot203; tph1bf234jy/f234jy | Complex | 2 figures from Pan et al., 2020 | Fig. 3 from Pan et al., 2020 | ||
| tph1aot204/ot204; tph1bf234jy/f234jy | Complex | 2 figures from Pan et al., 2020 | Fig. 3 from Pan et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Pan, Y.K., Jensen, G., Perry, S.F. (2020) Disruption of tph1 genes demonstrates the importance of serotonin in regulating ventilation in larval zebrafish (Danio rerio). Respiratory Physiology & Neurobiology. 285:103594
- Zimmer, A.M., Do, J., Szederkenyi, K., Chen, A., Morgan, A.L.R., Jensen, G., Pan, Y.K., Gilmour, K.M., Perry, S.F. (2019) Use of gene knockout to examine serotonergic control of ion uptake in zebrafish reveals the importance of controlling for genetic background: A cautionary tale. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 238:110558
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