Genomic Feature
ups8
- ID
- ZDB-ALT-200203-2
- Name
- ups8
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Blader Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 9: 21723127 - 21723137 (GRCz11) (1) Details
- Nucleotide change
- TCCAAATTCGG/-
- Variant Notes
-
The 11 bp deletion leads to a premature stop codon at amino acid 62.
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 11 bp deleted (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TAGAGGGGGCGGTGTTGACCCTTCGTGCACCCCGCCTACTAGTTCTTTCCTCGTTGTCTACGTCACTCGACCGAACTCCATGCAAATCGCTCCTCACTGGAACGCCATTGGCCGCTCGCTCATTTTAATCGCTGTCAAAACGCATCATATGGCCGCCGCTTTAACTAACTCTTCAACTCCACTAGGAAAAGTAACTCAAATGCACGTTCAATTAATGTGGATGTGAAGCGGCAGTCGGAGACGACACTAAACTGGCTACAGGAGCGAAAAGAGAGCCCGAAATTGTCAGCAAACGGTTGGGAATAAGCTGAATTCCACACTTCATCGGAGCTCCACTGGCTCGTGAAGCACCTGTTTCAAGCGGACTACGGAGCGCCGAAAGTTCATGCTTTTTCTCTGCTAGTTGAGAACTTTTAAGCCACTTGAATGTATAGCATGATGATGGAAACGGACCTTCATTCCCCGGGACCCCAAACCAACACGAACCCGGGGCAAACGGG
TCCAAATTCGG/- GGAGCAAAGCCAATCAAGACCGCGTAAAGAGACCCATGAACGCGTTTATGGTCTGGTCTCGGGGCCAGCGCCGAAAAATGGCACAGGAGAACCCCAAAATGCACAACTCTGAAATTAGCAAAAGACTCGGTGCTGAGTGGAAGGTGATGTCAGAGGCTGAAAAGCGGCCCTTTATTGATGAGGCGAAGCGGTTGCGAGCCATGCACATGAAAGAGCATCCGGATTACAAATACAGACCGAGGCGCAAAACCAAGACCCTGCTTAAAAAGGACAAGTACTCGTTGGCGGGTGGCTTGCTCGGCGGTGCGGGTGGTGGAGTCGGGATGAGTCCTGCGGGGGTCGGCCAGAGGTTGGAGAGTCCTGGGGGTCACGGAGGCTCGGCCAGCGCTGGCTACGCGCACATGAACGGCTGGGCGAACGGCACTTACTCCGGCCAGGTGGCTGCCGCGGCGGCGGCCGCCGCGATGATGCAGGAGGCGCAGCTCGCTTACAGCCAGCAC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| sox1aups8/ups8 (AB/TL) | Homozygous | ♀+/- ♂+/- | text only from Lekk et al., 2019 | ||
| sox1aups8/ups8; u711Tg; zf104Tg (AB/TL) | Complex | 3 figures  from Lekk et al., 2019 | 3 figures from Lekk et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Lekk, I., Duboc, V., Faro, A., Nicolaou, S., Blader, P., Wilson, S.W. (2019) Sox1a mediates the ability of the parapineal to impart habenular left-right asymmetry. eLIFE. 8:
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