Genomic Feature
vt1
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 15: 12229289 - 12229297 (GRCz11) (1) Details
- Nucleotide change
- AAGTTACCA/TG
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 2 bp inserted / 9 bp deleted (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
AACAAATTCACACCTCACCAACAAACTCTACTTTTCTACAAAGAAACACAAACAGAAGGCCAAAAGTATGACAAATACACAAGACCGATGCAAAATATCTACTCCCGTTCTACATATTCATAACTCAACAGCATATTCATATCTTGCATACAAATCATGCTATCTCCCCCATCTTTGCGCACGGGAACATGCAGATCCTACAGCCTCATAATCTTCCGTTCTTCGTTAATTACCAACTACAAAAACGATTTTACACATTTTATGCGACCGAAAAAAACATTTTCAACGAAGTTGCGTTAGTTTTGCAGAGAAACTTTATAAAATCCTAAAACGAGAGCGCACGATGGATTTACGCTAAATAACCATCCACTGTACATGCACATTTCTACTTCATTTAAGTTAATAAGCTGCACAGATACACATCAACATTATAAAGTAATAAAAAAGCCGCAATAAATAAACTCACTACATACCTTCTTGAAAAGAATACAGCAGGAGTA
AAGTTACCA/TG GCCACATGCCATAAATAGCAGGTATATTTCTCAGGAATGTTTTGCAATCCCGACGTGTGCACCGTGCAGTATTTGGCCAGGCTAGGCTCCGTGCAGGAGTGGTGACGATGCTCCCCGGCGATCTCTCCAGCCCTAGTCCCGGACTCTCCAGCACCGAGAAGCAGGGAAGACTTTGGTCCCGCCTCTCGTACCCTCCCATCCGCGGGACCGTCATTCGAGCGGCCCCTCCTTCGGTAGTCTAATGGTACGGCGGGATGGAGAGGTGCTGGTGCGGGGCCAGAGTGAGACGCGAAGAGGACGGCGCGCGGAGTTTTGTTGGTGGGGGTGGGTTGAGTGCATTCGAGAGGACAGGACTTAATGTGTTGTTGTTGTTGTTGTTGTTGTTGTGAGCGGTCCACGTGGCTGGAGACAGCAAGGGCATTCTGTGGCACCCAGTGCGCACCTGGGAACTAAATGACTGATTTTTACGCACGACGGATCTTTTTATTTGTATTTTCCGC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| dscaml1vt1/vt1 | Homozygous | ♀+/- ♂+/- | Fig. 5 from Ma et al., 2020 | ||
| dscaml1vt1/vt1 (AB/TL) | Homozygous | ♀+/- ♂+/- | 7 figures from Ma 马漫修 et al., 2019 | ||
| dscaml1vt1/+ (AB/TL) | Heterozygous | Unknown | 4 figures from Ma 马漫修 et al., 2019 | ||
| dscaml1vt1/+; cu2Tg | Complex | Fig. 4 from Ma 马漫修 et al., 2019 | |||
| dscaml1vt1/vt1; cu2Tg | Complex | Fig. 4 from Ma 马漫修 et al., 2019 | |||
| dscaml1vt1/vt1; jf5Tg | Complex | Fig. 9 from Ma 马漫修 et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Ma, M., Brunal, A.A., Clark, K.C., Studtmann, C., Stebbins, K., Higashijima, S.I., Pan, Y.A. (2023) Deficiency in the cell-adhesion molecule dscaml1 impairs hypothalamic CRH neuron development and perturbs normal neuroendocrine stress axis function. Frontiers in cell and developmental biology. 11:11136751113675
- Ma, M., Kler, S., Pan, Y.A. (2020) Structural Neural Connectivity Analysis in Zebrafish With Restricted Anterograde Transneuronal Viral Labeling and Quantitative Brain Mapping. Frontiers in neural circuits. 13:85
- Ma 马漫修, M., Ramirez, A.D., Wang 王彤, T., Roberts, R.L., Harmon, K.E., Schoppik, D., Sharma, A., Kuang, C., Goei, S.L., Gagnon, J.A., Zimmerman, S., Tsai, S.Q., Reyon, D., Joung, J.K., Aksay, E.R.F., Schier, A.F., Pan 潘於勤, Y.A. (2019) Zebrafish dscaml1 Deficiency Impairs Retinal Patterning and Oculomotor Function. The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(1):143-158
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