Genomic Feature
ibl53
- ID
- ZDB-ALT-190711-3
- Name
- ibl53
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Meijer Lab
- Current Source
- Other Pages
Notes
| Comment | Citation |
|---|---|
| short guide RNA was designed to target the first coding exon, such that the ... | Zebrafish Nomenclature Committee |
Variants
- Variant Type
- Delins
- Variant Location
- Chr 4: 17669711 - 17669731 (GRCz11) (1) Details
- Nucleotide change
- AGTTGGTAGAAAGCACATTCC/GG
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 2 bp inserted / 21 bp deleted in Exon 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CTATTGAAATTTTGGCAGGTGTCTTCTGTAAATCCTGGTATAATGTACGTTGCAATTTAGATAAGAAAATACACAATCTAAAGTTTAAAGAAACAAAACGAAGTTGTAGTTCACTCGTCCAGCTCCTTGCATTCATAGTTCACAGTTTTGAACTCCAGCCAACGTTAAACTTCTCTGTGTGGAAAACGAAACCAAACCAAGTTGCCTTTAAATACTTTTTCCACAATCCCTTTTACAACCTGCAGCTTTACATATGCAAATACCCGCTTAATACCTGCTCTTGTTACTAATATTATACATTTAAAAGCTATTTCTGTTGTCTTAGTATGTTTAAGTGTTGTGAATACGTCAAATCCAGATGTGTACACTAGCTTAAATCAAACAAAAGGTTAAAGGGAAATCACATACCTGATGTAAGGAAGGACAACATCAACATCTTGTCGATACAAAGCGATGATATACGAGATTATGAACGTGCTCGATGACCAGATAACCAGGAA
AGTTGGTAGAAAGCACATTCC/GG TTCCATAAACCAAAACATCTCGCCGCAGGGCTGAGGCTAATCGGCTCATCACCATTCAAGGAGACAAAAGTGAAGAGACTGGCGGAGAACAGACATGAAGAAAGACACGGACGTTCACTTCTCTTCACAAATACTCTTCACTCAATACGTGACGTTTATAACTGTATCTATAGTGTCACGTGGCCACTGGGAATCTGTCTTTCTCTTCCTCATTGTTTTACCCATAAAGTATTACCGCCAGCAGCAACATGTGAGCAACACGTAGAAGCTGGACTTTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTTACTTTTTACATGCATTAAACCAGTATGACATAGTTAGGTTTTTTTTCTTTACCTCAAAATCCTCTATTATTTCTTAATTTTTTTTTATTATTATTATTTTTGGTAAATGGAAATTTAATTTTTTTAAACAGTTTGTACAATAATTATTTTATTAATACTA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| dram1ibl53/ibl53 | Homozygous | ♀+/- ♂+/- | 2 figures  from 2 publications | ||
| dram1ibl53/ibl53 (AB/TL) | Homozygous | ♀+/- ♂+/- | 4 figures from Zhang et al., 2020 | Fig. 3 from Zhang et al., 2020 | |
| dram1ibl53/ibl53; ump2Tg | Complex | 2 figures from Zhang et al., 2020 | |||
| dram1ibl53/ibl53; zf155Tg | Complex | Fig. 3 from Zhang et al., 2020 | |||
| dram1ibl53/ibl53 + MO1-caspa (AB/TL) | Complex | Fig. 6 from Zhang et al., 2020 | |||
| dram1ibl53/ibl53 + MO4-gsdmeb (AB/TL) | Complex | Fig. 6 from Zhang et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Xie, J., Meijer, A.H. (2024) Xenophagy receptors Optn and p62 and autophagy modulator Dram1 independently promote the zebrafish host defense against Mycobacterium marinum. Frontiers in cellular and infection microbiology. 13:13318181331818
- Zhang, R., Varela, M., Forn-Cuní, G., Torraca, V., van der Vaart, M., Meijer, A.H. (2020) Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages. Cell Death & Disease. 11:277
- Sommer, F., Torraca, V., Kamel, S.M., Lombardi, A., Meijer, A.H. (2019) Frontline Science: Antagonism between regular and atypical Cxcr3 receptors regulates macrophage migration during infection and injury in zebrafish. Journal of Leukocyte Biology. 107(2):185-203
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