Genomic Feature
ecu4
- ID
- ZDB-ALT-190207-1
- Name
- ecu4
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Yong Zhu Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 21: 37437037 - 37437045 (GRCz11) (1) Details
- Nucleotide change
- GGCCATAGT/AGACAAA
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 7 bp inserted / 9 bp deleted in Exon 1 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
ATATATATATATTTTTTTTTTTTTTTTTTTTTTTTTTTACTTTTAAACTTAAAGTTTAACACAGTTAAACAATAAATTGCATAAATTGGTTGTCATGATATAAAGATAAAAGGGGGTGTCTGAAAGGAACTTAATGCGGTTTACAGTCATTGGGTTTTATTAGACGTTTTTAAATAAATACTCAAATGCAAATGTAAATATATATAACAGCTAACTTCAACCCCATCGCAAAAACTACACACCCCAGAACATCCACCTCGACTCTGATTGGCTGGCGCCTCACCATTGTGTGTTTTTGGCTTCTGTGATTGGTGCACAGCTGCAGTCGACGTCGAGCCTCGATGTTCTCACGCACAGTATCAGAATCGAAATGGCTGAAGAAGCAGTCGAGCAAACTTCTGGAATCCTTCAGGAAATTTTCACGTCGCCACTGAACATCAGTTTGCTATGTCTTTGTTTGTTCCTACTTTACAAAATCATCCGCGGAGACAAGCCTGCAG
GGCCATAGT/AGACAAA CGGTTGAGGAGCCGCTGCCTAAACTCAAGAAAAGAGATTTCACTTTAGCAGATCTGCAAGAGTACGATGGACTGAAAAACCCAAGAATCCTGATGGCTGTCAACGGGAAAGTATTTGATGTTACAAGAGGGAAGAAATTCTACGGTCCAGGTATCAACTTAAATATCTCAATCGAGAGTGTGATCTCAAACTTATCTCAGCTGCTTGTTTTTGTTTGTTTGTTTGTTTGTTTGTTTTACGAGGAACTTTTTTTTAAATTACGCGTGAATAATCTATTGTGTTTTATTAAAATAGCATTGATTTAATTACTGACACGCCCTTTTGTGTTGCATGTTTTATGCCTAGTCATAACTGCTAAACACTTCAAAACTATCATGTTAACTAGTAACACGCAACCTACAGAAGTGTGTTTGTGTTTGCATTGTTGTTACACTAACACCAAAACGCTGTTCTGGTATTTTCTTTCTTTTAGTAGCTTTTGTGCACACTTTTGCAATGCC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| pgrmc1ecu4/ecu4 | Homozygous | ♀+/- ♂+/- | 3 figures  from Wu et al., 2018 | 4 figures from 2 publications | |
| pgrmc1ecu4/ecu4; pgrmc2ecu10/ecu10 | Complex | 2 figures from Wu et al., 2019 | 2 figures from Wu et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Wu, X.J., Zhu, Y. (2019) Downregulation of nuclear progestin receptor (Pgr) and subfertility in double knockouts of progestin receptor membrane component 1 (pgrmc1) and pgrmc2 in zebrafish. General and comparative endocrinology. 285:113275
- Wu, X.J., Thomas, P., Zhu, Y. (2018) Pgrmc1 Knockout Impairs Oocyte Maturation in Zebrafish. Frontiers in endocrinology. 9:560
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