Genomic Feature
umo10
- ID
- ZDB-ALT-180816-15
- Name
- umo10
- Synonyms
-
- zf1080 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Wei Ge Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 20: 26382007 - 26382089 (GRCz11) (1) Details
- Nucleotide change
- ATGAGGGGGCTGCTTGATCCACCGCCAAGCGTCTGTAGATGTTCCTCGTGGGGGTCTGGGGGAGCCGGGTAGTATCCCACTGA/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 83 bp deleted in Exon 2 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
ACTGGGGGAAAAAATAAACAAGGGGGCTGATAATTCTGTAATAATAAACTGTAAGTATGAATAATTTTGCAAAGCATTAATTAATCATATTTCAACATTAATACATTAATAACATTAACATTAGTTAATGCACAGTAAATGAACATTCTTTAACTTAAATAACATTAACTAACATTAACAAAGATCAATTATTACCCGAAATAAAAGTGTTATTTGTATGTTCATGTTAGTAAATACATCAACTCAAAGACCATTATTTTAAAGTGTTGCCATATATTTTTATATATTATATTATATATTTCTAACTTTATTTAATAGTTTTAACTAATTTCATATTCATCATTTACTTAATTAAAGCCTGAGCTGAAATTTGCTGCTGCACTGACCTGTAGACGGTGCTGGACGAGGAATCCAGGTAGTAGGACACCTGATGAGGGGTGGTGTGGTGTCCTCCGTGATGGCTCAGATACGGGGACAGCTGTGGGCTGGAGGGTGCGAAC
ATGAGGGGGCTGCTTGATCCACCGCCAAGCGTCTGTAGATGTTCCTCGTGGGGGTCTGGGGGAGCCGGGTAGTATCCCACTGA/- AGCAGGCTCTGCAGGCGACGAGGTGCCGAAGGTCTGTGTGGGGTTCGGGTACTCATAAGCTCCATCTAGGTAGTTGACAGAGGAGCTGATGCCCCCCGCGCTGTGCTCCTCCTTAGGGTACATGGGTGAGAGTTTGTGGGCGGCAGGTGGCGAGGAAGGTTCCTCCAGGGCTTCTCTCTCAGGACTCGGGCTGGTCCTGCGTCGCTGCCTGGCACCAACAGCCTCTCCGCTGGTCTGCCCTCCAGACATCACCATGGAAACACACACGCAGGAAGCATGACTTAGGGTACTATCTGTTCATAAGCAAAAGACTGTTTCTGTCTTTTTTAAGCTCAGGCTTCTTTTTTTCCACCTCCCACAGTCTTTCTCAAACTCTCTCCCCCTTGTTCTGCTTCGCTTCCGCTTCACTCTCTCGCTGCTCTGCCTACTCCTCCTAAAAAAAAACTACCTTCCTCTCCTACAGTCCTCCTTGGGCTGAGAGGACAAAGTATGATGTTTTT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| esr1umo10/umo10 | Homozygous | ♀+/- ♂+/- | Fig. 2 from Lu et al., 2017 | Fig. 10 from Lu et al., 2017 | |
| esr1umo10; esr2aumo12 | Complex | Fig. 8 from Lu et al., 2017 | |||
| esr1umo10/umo10; esr2aumo12/umo12 | Complex | 5 figures from Lu et al., 2017 | |||
| esr1umo10/umo10; esr2bumo13/umo13 | Complex | Fig. 2 from Lu et al., 2017 | |||
| esr1umo10/umo10; esr2aumo12/umo12; esr2bumo13/umo13 | Complex | 4 figures from Lu et al., 2017 | |||
| cyp19a1aumo5/+; esr1umo10/umo10; esr2aumo11/+; esr2bumo13/umo13 | Complex | Fig. 6 from Song et al., 2019 | |||
| cyp19a1aumo5/umo5; esr1umo10/+; esr2aumo11/+; esr2bumo13/+ | Complex | ||||
| cyp19a1aumo5/umo5; esr1umo10/+; esr2aumo11/+; esr2bumo13/umo13 | Complex | ||||
| cyp19a1aumo5/umo5; esr1umo10/+; esr2aumo11/umo11; esr2bumo13/+ | Complex | Fig. 6 from Song et al., 2019 | |||
| cyp19a1aumo5/umo5; esr1umo10/+; esr2aumo11/umo11; esr2bumo13/umo13 | Complex | Fig. 6 from Song et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Wu, K., Song, W., Zhang, Z., Ge, W. (2020) Disruption of dmrt1 rescues the all-male phenotype of cyp19a1a mutant in zebrafish - A Novel insight into the roles of aromatase/estrogens in gonadal differentiation and early folliculogenesis. Development (Cambridge, England). 147(4):
- Song, W., Lu, H., Wu, K., Zhang, Z., Shuk-Wa Lau, E., Ge, W. (2019) Genetic evidence for estrogenicity of bisphenol A in zebrafish gonadal differentiation and its signalling mechanism. Journal of hazardous materials. 386:121886
- Lu, H., Cui, Y., Jiang, L., Ge, W. (2017) Functional analysis of nuclear estrogen receptors (nERs) in zebrafish reproduction by genome editing approach. Endocrinology. 158(7):2292-2308
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