Genomic Feature
zf1067
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 1: 54345046 - 54345049 (GRCz11) (1) Details
- Nucleotide change
- GCAT/-
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 4 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CTCCCATTCAAAAAGTAGTTAGCACAATTTAATGACGCAATAAGCTAATCATCAGATTTTGTTACCAGTGTAAATTTTAACGTGGAGCAGTGTGATATGAAGTTGTAATATCGCTCTACATAATCCCTAACCCAACCTCAGAACCAATAAAATACAGTGTTGGTAGCATAATCTGACGGGTAAGGTACAATGCCAGTACACCAAGTGAAAAAACCCTCTTCGGTAGTTTGAATGTGTACTGCAATACTCAGCTCAACCACTAGGTGTCAATGCTTGATCCTCAGCCTTACCTGAGCAGTTAAAGTGCACTCTCTCCAGCAGCGTCTGCACCTGAGTTCCACCCCCGTCCGCCCACAGAGAACACGCCCCTCCGTCAGGTGGCAGGTTGGGGTGGAGCTCGATGTAGGCCACGCCCTCTCGGTCCATCCCGTCATCGGTGACGTGGAGGCTGAAGATGTAGGACTCCCTGTCCCGCAAGATGCCCTGCCGAAGCACCAGGC
GCAT/- GCTGTCGCTGCCTGTGGTTGTGGTATTCAGATCTAGAACCAGCGTCTCGTTACGCCGCGTCATCGCCGTCCACCGCTGACAACAAAAATGATGGAAATATGTAAATTTTATTACTTTAAAATGTATTATTTTTATTATTCATGGTTGAGATTATAGGTTAGTTTTTCCCAAAAGAATAAAGACTGACAACTGAGAAATTCACATGGAAATAGTTGGAATTTGAGAAGGAGACAGATTTAGTAATATACATTTCTTAGCCAGAAATGTAAGAGTTGTAAACAGAGGTTTGAGCTCTGAGTCAAAAAGGTCTTCAGGAATGTCATTCAACAAAAACGTGAGGGGAAGAAAATAAAACGTTTTCCAATTATCTCCTGGATTGGAGAATGAACCCCTCTCCAAAACAGTTGGATTTGAACAGCACTAAAATACATGAAAAAAATGTAGCCTTGAAGGTTTTGCACTTAAAACAGAGGTCGGAACAGGCTGGGAACGCTTTATGC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| pkd1azf1067/zf1067 | Homozygous | ♀+/- ♂+/- | 4 figures from Zhu et al., 2017 | ||
| pkd1azf1067/zf1067 + MO4-atg5 | Complex | Fig. 4 from Zhu et al., 2017 | |||
| pkd1azf1067/zf1067; pkd1bzf1070/zf1070 | Complex | Fig. 1 from Zhu et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- Ellis, J.L., Evason, K.J., Zhang, C., Fourman, M.N., Liu, J., Ninov, N., Delous, M., Vanhollebeke, B., Fiddes, I., Otis, J.P., Houvras, Y., Farber, S.A., Xu, X., Lin, X., Stainier, D.Y.R., Yin, C. (2022) A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatology communications. 6(11):3083-3097
- Zhu, P., Sieben, C.J., Xu, X., Harris, P.C., Lin, X. (2017) Autophagy Activators Suppress Cystogenesis in an Autosomal Dominant Polycystic Kidney Disease Model. Human molecular genetics. 26(1):158-172
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