Genomic Feature
mb14
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 5: 65949152 - 65949161 (GRCz11) (1) Details
- Nucleotide change
- TCCGGCCCCA/CC
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Net 10 bp deleted (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
AGGCAAGTCATTGTATAACAGTGGTTTGTTTTGTACACAATTGAAAACAAATATTGCTTAAGGGGGCTAACATTACATTAAAACATTAAACATTAAAATGATTTCTAAAAAATTAAAAACGTCTTTTATTCTAGCCAAAATAAAACAAATACATTTTTTTCCAGAAGAAAAAATATTATAGGAAATACTGTGAAAAGTTCCTTGCTCCATCATTTGGGAAATATTCGAAAAAAGAAAAACAAATTCACAGGAGGGCGAATAATTCTGTAAATCTATTTATGATAAAATAGACGTGTCAAACAGTGTGATGCAAAAGGCTATTTTTCACGAGCATGTTGACAGGTGTTTACATTTTGCATTCCACTTTGACGTGTCAAGTATTTGCTTTATTTGCAGCGCTTGGGGATTTCGATGAGCCCAAACGCTCTTCGCTCACCATGTTTGGGGTGTTGACCGCAGCTGTGAGGATCTACCAGGACCGACTGGGATACGGCATCTAC
TCCGGCCCCA/CC TCGGGACAGCTGTCTTTATGATCACAGTCAAATGGGTGAGTTTGAGACACGTCAGATGGGTCAGATTCTTCCAGTTAAGGTAGAGTTGTCCTGGAGGGCCAGTGTCCTGCAAAGTTTAGTTTCAATCCCAATCAGACACACCTGGGCTAGCTAATCAAGCTCTTACTAGGCTTTCTAGAAACATCCTTGCAGGTGAGTTGAGGCAAGTTGGAGCTAAAATCTGCAGGACACACCGGCCCTCCACGACCGAGTTTGGACACCCCATGAGTTAAGGAATTAGTTCATGTGAATGACGATATCTGTGAGATGGTCAAAGTTGTCCACATTAGTTTACACAGAATTTTATTTTATTTATTTATTTTTTTGTTAATAAAAAAATAACAGATTGTATGTACATTATATAACAGCAGTACATTGTAAAAAGTAAGAAGACTTTCGTAAAAAAGTGAGCAAATCCATTGGTTTTAAATCTATCAGTTGCCTTTACTTTAAAAAGTGAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| mymkmb14/mb14 | Homozygous | ♀+/- ♂+/- | 6 figures from 3 publications | Fig. 6 from Shi et al., 2018 | |
| mymkmb14/mb14; sw105Tg | Complex | Fig. 7 from Luo et al., 2022 | |||
| jam2ahu3319/hu3319; mymkmb14/mb14 | Complex | 2 figures from Si et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Yong, P., Zhang, Z., Du, S. (2024) Ectopic expression of Myomaker and Myomixer in slow muscle cells induces slow muscle fusion and myofiber death. Journal of genetics and genomics = Yi chuan xue bao. 51(11):1187-1203
- Luo, Z., Shi, J., Pandey, P., Ruan, Z.R., Sevdali, M., Bu, Y., Lu, Y., Du, S., Chen, E.H. (2022) The cellular architecture and molecular determinants of the zebrafish fusogenic synapse. Developmental Cell. 57(13):1582-1597.e6
- Shi, J., Cai, M., Si, Y., Zhang, J., Du, S. (2018) Knockout of myomaker results in defective myoblast fusion, reduced muscle growth and increased adipocyte infiltration in zebrafish skeletal muscle. Human molecular genetics. 27(20):3542-3554
- Si, Y., Wen, H., Du, S. (2018) Genetic Mutations in jamb, jamc, and myomaker Revealed Different Roles on Myoblast Fusion and Muscle Growth. Marine biotechnology (New York, N.Y.). 21(1):111-123
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