Genomic Feature
hdb12
- ID
- ZDB-ALT-180207-12
- Name
- hdb12
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one insertion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Maria Leptin Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Insertion
- Variant Location
- Chr 16: 42004415 - 42004416 (GRCz11) (1) Details
- Nucleotide change
- -/TTATTATTT
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 9 bp inserted in Exon 1 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
CACTATTTTTTTATTGTAAATACATTTTAATAAAACTAATCATTCAAAATGAAAAGACTGCATTAAGATAAAACAAAAGATTGAGTAATATAAAAAAACACCAAAATAAACAATAATCACATATAAAAGTAGAAAGGGTGTATCAGGACTTGGGCCCCATGGCTGAGGTTGCCTAGGGTCCCCAATTCGCTAAATCCGCCCCTGCATATCTATAATAACTTTAAAGAATGACAGACTGACTTTTTTCCGCGTTTGTCATTATGTGAAGCTTTACTCACCTTGCCCTGTGTTCTCCAAGAGCTCCTCTGCTACTGCATTACACTTGATACCCCTTAAAATGTCCACTGTTACAGAAACCGCGTCAGATGTGAAAGTGTTGACCAATAAATCAACCAGATCTATCTCGTCTTTCAGCTTTTCGATTGTAGATTTTCGGACGCGCGGTTCCTGCTTCCGATCGCCCAGTCTGCTTTGAAACCTTCTTAGATTATCCGCCCCAAT
-/TTATTATTT ATTACTTAAAGCGTCCTGAAGATGGTCCTTGATAGATTTGGCCATGTTTAGCTCAGGGCGCTGACTGAATGCCGAAGGTCAACACAATGTGTTTCTTTCCCTTTTTCTAACAGATTGCCCAATCAACAAGTAATGAACATGTATGTTCCTGCACAATCCTCTAGGTGACTTGTGCCCATTTTACTTCGACATGAGGAAATAAATATACTGCATAAAACGTATATATAAAGTCAGAATGATTCGCCCTTCTTTGAATTTGTTTTTCATTTTTAAAAATTTCCCAAATTATGTTTAACAGAGCAAGGACATATCTGATGATATTTTTTCTTCTAGAGAAAGTTATTTTTGTTTTTTTTTGGCTAGAATAAAACCAGTTTTTAATGGTTTTAAAACCATTAAATGGGCAATATTATTGCCCCCCTTAAGCAATATTTGTTTTTGATTGTATAATGTAGACAATGACTTGCCTATTTTTACCCTGACTTGCCTAGTTAACCCAAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| caspahdb12/hdb12 | Homozygous | ♀+/- ♂+/- | Fig. 2  from Frame et al., 2020 | ||
| caspahdb12/hdb12; la2Tg | Complex | Fig. 2 from Frame et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Frame, J.M., Kubaczka, C., Long, T.L., Esain, V., Soto, R.A., Hachimi, M., Jing, R., Shwartz, A., Goessling, W., Daley, G.Q., North, T.E. (2020) Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production. Developmental Cell. 55(2):133-149.e6
- Kuri, P., Schieber, N.L., Thumberger, T., Wittbrodt, J., Schwab, Y., Leptin, M. (2017) Dynamics of in vivo ASC speck formation. The Journal of cell biology. 216(9):2891-2909
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