Genomic Feature
p190
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 5: 67775394 (GRCz11) (1) Details
- Nucleotide change
- A/G
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>C (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Ser>Pro at position 174 (1)
- Flanking Sequence
-
CTGCTGTAAGAAGTCTTTAAAGCCGGGTATATGTCCAGCCCTCAGAGCAAAGCCAATGGTTCCTCCCATGACGTCAAGATACTCTGGTTTGGCGACTAGACTGGAACTGGCCCATGCTTCGCTCGCCAACCAGACGCGGTCTGTGATGTTTCGTCTCACCATCTCTTTAACTAACGGCTCGATATCTGGTCCGCTAGCAAACACAACAATTACCTTGGCGGATGAGTTCTGGATGCGATCTGCCAGGCGACGAATCTCAGCTTCGTCAACGTACTGTGAAATTAAAACATTGAGGTCAATGCAGATGTCCCGGTGAAACATTTCATTCTCAAACTTTTCAATGCCTGGCCGGCCGTATTCGTCGTCAGAGGCGATAGCAATCACCCAGTTCCACTGGAAGTGCTCGATGATGGCAGCCATGGCAATCGCCTGGTACTCGTCTGTAGGGATTGTCCTCATGAAGGATTTGTACTGGTTTTTGTTGCTCAAAAGGCGGCTGG
A/G TGAAGCATAGCTAATCTGAGAGACAGTAGAAAAGAGAAATAGTTGGAAAAAAATTACCCATAAAGGATGCTCATATTTCCGTCTATCTACGCAGCTCTTTTTCAAAAGGTCACAAAGTTGGACTTCAGAAGTACATCATTTATTCAGAACCATTCGTTTATTTTTATAACTGATTTTAAAAGGCACAATATGTAAGATTTCTTCATGAAGATATTCAAATACTACTAGAACGATATTGTATATTTAACTGACTTTTGTACTTGTTTTGTACAAATGTTGTAAAGAATTTTAAATGCAGAGAAATAAGCAGTTTTGAATTGTCACTAAAGCAGGGAAACAGCCGCTTTAATATGTTGTGTGTTTATAAGACTCCACAGAGCAGCATTCCCAACATAAGATGTTAATATTAGGACAGTCACGCACCGCTATATGACTGTTTTGAGGATTGCATATGAAGGTAAGACGGCACTTGTAATGAAAAGGAAGGGAATCGCGACGTT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| casrp190/p190 | Homozygous | ♀+/- ♂+/- | 3 figures  from Jain et al., 2018 | ||
| casrp190/p190; nkhspgffdmc130AEt; p201Tg | Complex | Fig. 3 from Jain et al., 2018 | |||
| ap2s1p172/p172; casrp190/p190 | Complex | Fig. 6 from Jain et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Shoenhard, H., Jain, R.A., Granato, M. (2022) The calcium-sensing receptor (CaSR) regulates zebrafish sensorimotor decision making via a genetically defined cluster of hindbrain neurons. Cell Reports. 41:111790111790
- Jain, R.A., Wolman, M.A., Marsden, K.C., Nelson, J.C., Shoenhard, H., Echeverry, F.A., Szi, C., Bell, H., Skinner, J., Cobbs, E.N., Sawada, K., Zamora, A.D., Pereda, A.E., Granato, M. (2018) A Forward Genetic Screen in Zebrafish Identifies the G-Protein-Coupled Receptor CaSR as a Modulator of Sensorimotor Decision Making. Current biology : CB. 28(9):1357-1369.e5
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