Genomic Feature
sm10
- ID
- ZDB-ALT-170804-2
- Name
- sm10
- Synonyms
-
- smu3 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Yiyue ZHANG Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 6: 33978301 - 33978308 (GRCz11) (1) Details
- Nucleotide change
- GTGCATCC/CAAAGTCTTTTCAAAAGCAAAAGTCTTTTCAAGTCTTCAAAGTCTTTT
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 48 bp inserted / 8 bp deleted in Exon 3 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
ATGTTAGGTGGTACTGTTATTTAAGTAATCATAAAGATGCCTGCCTTGTTAATTCTGTCATAGAAATAGCAGCTGTTGGAGATTTTCATATCTTGAAAATCTTTTTTTTTAAATGTATATGTATACAGCTTCCAGCACTCTAAACATCCTCAGTTTTTTTTTCAGTTATCATCCTCAGTTATCATTATGAGTAAAATAAGGGCATTTTATAAACCAACCCATCAGTATTTTAAAACTTTAATCCAACTGTTGGGTTTGTCCACATTTTGCACAATTTCTAAATTAATTTAAGAATTGCAGGAATCTCTGTATGCTAGATTATTTTAATTGATTGATTGATCAGTTATTAACTTTATTTATTAGCTAACTGGAAGTAAACTGTCTAACTAGCTTTTTCTTTATAGTAAATGAGCCAATCATTTAAATGAAATCTACAAGATGAAATGTTCAGAACTCTCACCCTTCAATTATATAAAGAAAATCATAGGACTTTTCAACAG
GTGCATCC/CAAAGTCTTTTCAAAAGCAAAAGTCTTTTCAAGTCTTCAAAGTCTTTT CAAAAGCAAGTGAAGTCTTCTAGATTCCTGGTGAAACATTTTGGGTCCTCATCCATAGCCAATAACTCTGAAAAGAATGAAAAAATTCTTGTAGCTAAAATACTAACAAAACGCATAGTTTTGATGCATGTATCCTTTTACACTTTTCTCTACTAAACGCTCGCTCAACATAATGTGTTGTATTTAACACTTTCCTCTTCAAAAACAGATCAGCTTCTTTGCAGAATGAACATAAAATACAATCATCTAAAATAAAGTCACCTGACTGGTGTTTCTTACCTGGCTTTGGTTGGCGAGGTTCTGAATTCACCTGTTTGTAAAGACAAAAATGTAAAATCCACCAGATGAAAACTGGATCCATGTTGATGGGGGTCCATACACAACACTTAAAATTAACGTCTAGATAAGATAGATTTGTGTCAAGTGCTTAATGTTTTTAGGAGAGGGCGGGGAGGTTGGTAACTGGTCATCTGAAGGGGCCCAATGAAATAGGAAGTGGT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| mplsm10/sm10 (AB) | Homozygous | ♀+/- ♂+/- | Fig. 1 from Lin et al., 2017 | ||
| mplsm10/sm10; la2Tg | Complex | 4 figures from Lin et al., 2017 | 4 figures from Lin et al., 2017 | ||
| mplsm10/sm10; sm9Tg | Complex | Fig. 6 from Lin et al., 2017 | Fig. 6 from Lin et al., 2017 | ||
| mplsm10/sm10; sm9Tg | Complex | 2 figures  from Lei et al., 2023 |
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Supplemental Information
- Genotyping protocol
- None
- Lei, W., Liu, Z., Su, Z., Meng, P., Zhou, C., Chen, X., Hu, Z., Xiao, A., Zhou, M., Huang, L., Zhang, Y., Qin, X., Wang, J., Zhu, F., Nie, J. (2023) Hyperhomocysteinemia potentiates megakaryocyte differentiation and thrombopoiesis via GH-PI3K-Akt axis. Journal of Hematology & Oncology. 16:8484
- Lin, Q., Zhang, Y., Zhou, R., Zheng, Y., Zhao, L., Huang, M., Zhang, X., Leung, A.Y., Zhang, W., Zhang, Y. (2017) Establishment of a congenital amegakaryocytic thrombocytopenia model and a thrombocyte-specific reporter line in zebrafish. Leukemia. 31(5):1206-1216
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