Genomic Feature
uwm33
- ID
- ZDB-ALT-170530-2
- Name
- uwm33
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Huttenlocher Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 9: 48088146 - 48088153 (GRCz11) (1) Details
- Nucleotide change
- CCTGTTCC/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 8 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
GATATTTTTCAAGAGACTAGTATTCAGCTTAAAGTAACATATAAAGGCTTAACTAGGTTAACTAGGCAAATTATTGTATAACGATGGTTTGCTCTGTAGACAATCTGACAAAACATATTGCTTGAGCGAGCTAATCATTTTGACCTTAAAATAATTTTAAAAATTTAAAAACTGCTTTTATTCTAGCCAAAATAAAACAAGTACGACTTTCTCCAGAAGAAAAAATATTGTAGGAAATACTGTGAAAAAATGAATTGCTCTGTTAAACATCATTTGGGAAATATTTAAAAAATCGAAATAATTTTGACTTCAACTGTATATCCTCTTGCTAACATTGCACATAACTGTTTCACCACAGCTTTTGTTTATCATTTTCATAACTCCCCTAACAGATCCAAACAGCTCTAATCACCTGGTAGACTTCCACGAGTTCTACTACGAAGAATTCAACGATACAGATTTCAGCAACTTCACGTTTGTTCCCGACGAGAAGACAATCC
CCTGTTCC/- TCCATCACAATGGCATCCGCTGTCAACATTTCATTCAGCGTCTTCTACGTTTTCATCTTCCTGTTGGCTATCCCCGGGAATGTGATTGTCGGCTGGGTCATCGGCTCCAACCGGCGCTTGCTGTCGGCATCAGATGTCTACTTATTCAACCTGATGCTAGCCGATACACTACTAGCGCTAATTCTGCCCTTTTCTGCAGTCAACGTCATCCACGGTTGGGTCTTCGGCAATGTCGCGTGCAAGCTAGTTTCATTAGTAAAGGAAGTCAACTTTTACACTAGCATTTTATTTTTAGTGTGCATCAGCGTGGATCGCTATATGGTGATCGTACGCGCTATGGAGTCCCAGAAGGCCCAAAGAAGACTCTGCAGTGGAGTCGCGTGCGGATTAGTTTGGGTTTTGGGTTTAGTGCTCTCACTGCCGTCATTCTACAACGAGGCGTTTTTCGATAAACGAATGTTCAATCAGACTATTTGCGCTGAACGATTTGAGACTGATCA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| cxcr1uwm33/uwm33 | Homozygous | ♀+/- ♂+/- | Fig. 1  from Powell et al., 2017 | ||
| cxcr1uwm33/+ (AB) | Heterozygous | Unknown | |||
| cxcr1uwm33/+; uwm7Tg | Complex | ||||
| cxcr1uwm33/uwm33; uwm7Tg | Complex | ||||
| cxcr1uwm33/uwm33; uwm7Tg + MO1-cxcr1 | Complex |
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Supplemental Information
- Genotyping protocol
- None
- Powell, D., Lou, M., Barros Becker, F., Huttenlocher, A. (2018) Cxcr1 mediates recruitment of neutrophils and supports proliferation of tumor-initiating astrocytes in vivo. Scientific Reports. 8:13285
- Powell, D., Tauzin, S., Hind, L.E., Deng, Q., Beebe, D.J., Huttenlocher, A. (2017) Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell Reports. 19:1572-1585
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