Genomic Feature
t22074
- ID
- ZDB-ALT-170119-18
- Name
- t22074
- Synonyms
-
- HA343 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 4: 13591567 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Arg>Stop at position 203 (1)
- Flanking Sequence
-
TAATTTGCAAGGACTATTAATATGTAACTTTTTTTTTTAATTGGTAAATGTATTTTTTATAGCAGTATTTTGTGTGAAAATATGTATGTAGTCTTTTTGTTTTCGTTTATGTACTTTGGGACAAGCGTTTTAATTATATTTGCGGTATATTAATCTGCATTTTAGTGTTCTGCCAAGTCAAGTTATAACTTACACCTTGAAAACTATCACTGGACAGTTTTTAAATTTGGACATCTTTGTTAACCGAGGCATAGTTTTTATGATGGTTCATATCTCTGTGTGTGTCCTCATCAGTTGTTGCTGTTATTTTGCTTGCACTTCTCCTCTGTTCTATTCTCTCATTCTCTTCATGCAAATCATATCTGCGGTTATATGGTGTATGAACATTCATTTAAATGAGTTGACTGTGATCTGACTGTGGGTATTTCACTTATCTCTGTGATCAGGTGACGTGTGCGGAGAAGTCTGGCCACGACGAGAAGATGCTCATCAAGGTGTTC
C/T GATGTTTGGGGAGCTGGTTTAATTTAGGAGTGCTGGACAACAATTTCATGGCAAACAATCAACTGCTGATGATTCTCTTCCAAGTGCTGGTAAGATGGAGTCAGATAGTCACTTTATTTTCCCACTTTTTCTTACTTTTATTTTAAAAATGTTTTTTCCCCACTCGTCATTGAAGCAGAGGGATGAGACGTCTACAAACCTGCATGAGGCAGCATCAGACTGCGTATGCTCAGCATTGTATGCAATCGAGAATGTGGCCATTCACCTGCCGCTGGCCATGCAGCTCTTCCAGGGAGTCCTTACTTTAGAAACAGCCTACCACATGGCCGTGGCCCGAGAAGACCTCGACAAGTATGTATGGCTCTGCTTGTGAATAATATAAAGGGTTCATCGAATTTCTGTAATATTCTGGAAAAGGTATATTCCAGACGTTGGAAGTCAGGGAATTTTTAGGTATTTTATTTATAATTTATTTTAGTCATGGAATATCGGGAGTTTTT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| tnpo3t22074/t22074 | Homozygous | ♀+/- ♂+/- | 2 figures  from 2 publications | 2 figures from 2 publications | |
| tnpo3t22074/t22074; fr101Tg | Complex | Fig. 5 from Iwanami et al., 2016 | Fig. 5 from Iwanami et al., 2016 | ||
| gemin5t26393/t26393; tnpo3t22074/t22074 | Complex | Fig. 5 from Iwanami et al., 2016 | |||
| tnpo3t22074/t22074; upf1t20450/t20450 | Complex | Fig. 4 from Lawir et al., 2020 | Fig. 4 from Lawir et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- O'Meara, C.P., Guerri, L., Lawir, D.F., Mateos, F., Iconomou, M., Iwanami, N., Soza-Ried, C., Sikora, K., Siamishi, I., Giorgetti, O., Peter, S., Schorpp, M., Boehm, T. (2021) Genetic landscape of T cells identifies synthetic lethality for T-ALL. Communications biology. 4:1201
- Lawir, D.F., Sikora, K., O'Meara, C.P., Schorpp, M., Boehm, T. (2020) Pervasive changes of mRNA splicing in upf1-deficient zebrafish identify rpl10a as a regulator of T cell development. Proceedings of the National Academy of Sciences of the United States of America. 117(27):15799-15808
- Iwanami, N., Sikora, K., Richter, A.S., Mönnich, M., Guerri, L., Soza-Ried, C., Lawir, D.F., Mateos, F., Hess, I., O'Meara, C.P., Schorpp, M., Boehm, T. (2016) Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development. Cell Reports. 17:2259-2270
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