Genomic Feature
t20463
- ID
- ZDB-ALT-170119-15
- Name
- t20463
- Synonyms
-
- HK017 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 23: 24243230 (GRCz11) (1) Details
- Nucleotide change
- G/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>A (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Gln>Lys at position 562 (1)
- Flanking Sequence
-
GTTTTGAAGATGAACAAATGTCTCAGGGTTTTGGAATGGCATGAGAATGAGTAATTATTGACAGAATTTAAATTTTTGGGTAGACTAACCCACTAATAATCAAAATAATAAAATAATCACATTTATTGTCAGGCAAATTACATAATCGTGACAGCCATTAGAGGAGAGAAAAGGTTAAGAGACATTAAATCAATAAAAATGTCACATCTTACCTGTGTGGATGATGATATGCTTTGACAGATCGCCCACGTTGACAAATGCTTTATTGCAGGTTTGGCATTTGTGTGGTCGGATGTTGTCATGGTGACGGATGTGATTTGCTAGCTGGCTGGACTGGACAAACCTACGAGTTGGGATTGAAACATTTTAATATTTGGTGCCACTATGAATCTGTGTAAAATCATTGATGCTGTGTCTGAATTACCTTTTGCCGCAGCGGTCACACACATATGGCTTCTCTCCGGTGTGCTGGCGAACATGAGCGATGAGTGAACTGGCCT
G/T TGTGAAGCCTTTTCCACAAATCAGACACAGACAGGGCTTTTCACCTAAAACAGTGTAACAAAGAGACTAATTGAAAAAGGTATATGACGGTGTAAATATCACATAAACTTTTATCGCAAGAAACGGCAACACAATTTTGAAATAAGCGACTTTAACAGGTGTAAAAGCGTACTACATATCTGAGCATTGCTTATACTGTACATACTATTATCGGTTTAGAGTGAACAGAATTTCAATAGGCATCTCTTTACAGTCACTTTTCATTGTAAATGTTAGATAATCCATTAACGTCCATCAACTGTAAGAGATTCATTTGTTACAGACATTATAATGTTAATGTCATTTTAACAAATACAACTAAACTTTAGCCTTTTTCAAACATACAGACCTTTCAGAAAAATTACCAGCAACTTTTCGGTGTGAACAGGCCCTTTTTGAAAATACCGGTAAGTTCCTTCCAGCAATTTTCAGGAAACTAAAAATTGCCCAAAAATGTATCA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| zbtb17t20463/t20463 | Homozygous | ♀+/- ♂+/- | Fig. 1  from Lawir et al., 2017 | 3 figures from Lawir et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- O'Meara, C.P., Guerri, L., Lawir, D.F., Mateos, F., Iconomou, M., Iwanami, N., Soza-Ried, C., Sikora, K., Siamishi, I., Giorgetti, O., Peter, S., Schorpp, M., Boehm, T. (2021) Genetic landscape of T cells identifies synthetic lethality for T-ALL. Communications biology. 4:1201
- Lawir, D.F., Iwanami, N., Schorpp, M., Boehm, T. (2017) A missense mutation in zbtb17 blocks the earliest steps of T cell differentiation in zebrafish. Scientific Reports. 7:44145
- Iwanami, N., Sikora, K., Richter, A.S., Mönnich, M., Guerri, L., Soza-Ried, C., Lawir, D.F., Mateos, F., Hess, I., O'Meara, C.P., Schorpp, M., Boehm, T. (2016) Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development. Cell Reports. 17:2259-2270
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