Genomic Feature
fu45
- ID
- ZDB-ALT-160412-1
- Name
- fu45
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Lecaudey Lab
- Current Source
- Other Pages
Notes
| Comment | Citation |
|---|---|
| fu45 has a single-nucleotide deletion in the third exon of amotl2a, resulting ... | ZFIN Staff |
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 6: 27993791 (GRCz11) (1) Details
- Nucleotide change
- T/-
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 1 bp deleted in Exon 3 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
GCCGAACAGGACGACAGCATGTGGGATGCGAAACGAGAGCATGCACGCTCACTAAGTGAGCGTCTTTTGCAACTCTCACTAGAGAGAAATTGTGCCCATGACAATATTCCCATGAGCTCATCGCATAGTTATCCCCAACTCTCTAATAACCACTCTGATACAGTTGTGAATGAGCAGTCAGTTCATCAGCCAGACCAACGGGGTCCTCCCCCGGAGTACCCCTTCATGGTCAGATCCCCTGGATATATGCTTAGTCATTCACAGGAACATGGACACTATTATAATGAGCCCCCTCCTGCCTTCCATTCACAGCATTACAGGTAAAATTATATTTTGGTCACATTGTATATACTGTACACTCTATATGAACATCATGGGTGTTCTAATGTTTATTTTTGTCTCTCTCAGGTTATTTCCAACACAGCCACAAGCACCTCGTCACAATGGCCTGCCCACATTGACCCCTGCTGGCCAGGATGTCAATGTTGGAGGATACAGCA
T/- CCCAGCGAACAACTTCCAAATGGAGCAGCTTATTAAAGAGAACGAAAGACTGAAAAGAGAAGTGGACAGCTACAGTGAGAAGGCGGCAAGGTTACAGAAGGTAACAGGATTCTTTGTGTGATTGCAACTTCCTTGCAACCTTCTAGAACTGTGATGTTTTTGGTATGACCTCACATTTTGCCATGGATGCAAAAAGGCAGCTGTGTCCTTTGATTGTGAACTCAGACATGACCTACAAAGAGTGAGAACAAGAAATCATTGTGCGCTGGTGTCTTCTAGCCTCTGCATTCTAAGAAGATTAGCTCTCTTGCCGTGTAGGAATGCATGCAAGGGAGAGGATCACAAGGACTTCAATTTAATTTGAAAAGGACACATTCTTGGTCACTGAGTGAAAATTCCCAGTAACTTATTTAGCATGCGAAACAACACTGAATTTACCCATGCCTAAAATGCCATGCATTTTTCTGTAATGTGATAATGTCATCACTGAAATACCAGAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| amotl2afu45/fu45; ncv1Tg; ncv36Tg; nkuasgfp1aTg | Complex | Fig. 6  from Nakajima et al., 2017 | |||
| amotl2afu45/fu45; zf106Tg | Complex | Fig. 4 from Agarwala et al., 2015 | Fig. 4 from Agarwala et al., 2015 | ||
| amotl2afu45/fu45; zf106Tg | Complex | Fig. 4 from Agarwala et al., 2015 | Fig. 4 from Agarwala et al., 2015 |
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Supplemental Information
- Genotyping protocol
- None
- Nakajima, H., Yamamoto, K., Agarwala, S., Terai, K., Fukui, H., Fukuhara, S., Ando, K., Miyazaki, T., Yokota, Y., Schmelzer, E., Belting, H.G., Affolter, M., Lecaudey, V., Mochizuki, N. (2017) Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance. Developmental Cell. 40:523-536.e6
- Agarwala, S., Duquesne, S., Liu, K., Boehm, A., Grimm, L., Link, S., König, S., Eimer, S., Ronneberger, O., Lecaudey, V. (2015) Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish. eLIFE. 4:e08201
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