Genomic Feature
fb103
- ID
- ZDB-ALT-160323-3
- Name
- fb103
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Langenau Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 7: 41355285 - 41355292 (GRCz11) (1) Details
- Nucleotide change
- CTTGGCAT/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 8 bp deleted (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Asp>Stop at position 3612 (1)
- Flanking Sequence
-
TTTGCTTTATTTCGGCTAGAATAAAAGCAGTTTTTAGTAAAAAAAAAAAAAACATTTTAAGGACAAAATTATTTGCCCATTTAAGCTATATTATTTTTCGATAGTCTACAGAACAAACCATCGTTATACAATAACTTGCCTAATTACCCTAACCTGCCTAGTTAACCCAGTTAAGCCTAATAGGCTAATAATTCAGAGGGCAAAAAATTCTGCCTTCAACTATATATCATATATATACATACATGCATATATATATATATATATATAGAGAGAGAGAGAGAATATTTGTTATGTGATGACAGAGAGAGAAAGATATTTTATAGTTAAGACTTTTTATAAAGGAGTATTAAGTTTAAGATTATTTATTAATATTTGTATGCATATATGTAAACACACATAGCATATCAGAATTTTGGGCTTAATTTTATTAAACAAATCACAGTTATATGCAAGTTGTAAACCTGGATGAACTTTCTTCTGTAAGACCCAAATCTTGGAGA
CTTGGCAT/- CTCCAAGCAATTCAGTCATGTATTGTAGCTTCATTTTCTTTTTGTCCAGGTTTGGTTTGTCCAGTTGATTCTTCACCTCATCCCACCAGTCCTGTCAAACCATTAATTGAGAATCAATTCTTTGTAATGTCTTTGTAAGTTAAAATGCCCTAAGCAGCACCAACTAAAATCTGTCAGATCTGTTAAAACAGCTCCAGTTGGTACTTGAATTTTGGACAAAACTCACAGAGAAAAATGGTCCTATACCTTGAAAAGCATTTCAGGGTTTGAAAGTTGCTGAAGGGCATCTACAAACCCTTGGATGACACCACCTTTATCCAATAATGACTCCAGCCTGGAACATAAACAATAGTTTGCATGTCTCAATACGAGAAAAGCCAAAGCCACATCCAGAACTACAGAGATAAGTACACACTTCTCAACAAACTCTCGGTTCCTCTGACCACTTGCAGACTCCTCAAAAGTGTAGTTCTCACTGCTGATCATGTACGGGTATATGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| prkdcfb103/fb103 | Homozygous | Unknown | Fig. 3 from Tang et al., 2017 | ||
| mitfaw2/w2; prkdcfb103/fb103; mpv17a9/a9 (AB) | Complex | 2 figures from Moore et al., 2016 | |||
| mitfaw2/w2; prkdcfb103/+; mpv17a9/a9 (AB) | Complex | Fig. 2 from Moore et al., 2016 | |||
| mitfaw2/w2; il2rgafb104/fb104; prkdcfb103/fb103; mpv17a9/a9 | Complex | Fig. 3 from Tang et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- Solman, M., Blokzijl-Franke, S., Piques, F., Yan, C., Yang, Q., Strullu, M., Kamel, S.M., Ak, P., Bakkers, J., Langenau, D.M., Cave, H., den Hertog, J. (2022) Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects. eLIFE. 11:
- Somasagara, R.R., Huang, X., Xu, C., Haider, J., Serody, J.S., Armistead, P.M., Leung, T. (2021) Targeted therapy of human leukemia xenografts in immunodeficient zebrafish. Scientific Reports. 11:5715
- Yan, C., Do, D., Yang, Q., Brunson, D.C., Rawls, J.F., Langenau, D.M. (2020) Single-cell imaging of human cancer xenografts using adult immunodeficient zebrafish. Nature Protocols. 15(9):3105-3128
- Yan, C., Brunson, D.C., Tang, Q., Do, D., Iftimia, N.A., Moore, J.C., Hayes, M.N., Welker, A.M., Garcia, E.G., Dubash, T.D., Hong, X., Drapkin, B.J., Myers, D.T., Phat, S., Volorio, A., Marvin, D.L., Ligorio, M., Dershowitz, L., McCarthy, K.M., Karabacak, M.N., Fletcher, J.A., Sgroi, D.C., Iafrate, J.A., Maheswaran, S., Dyson, N.J., Haber, D.A., Rawls, J.F., Langenau, D.M. (2019) Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish. Cell. 177(7):1903-1914.e14
- Benjamin, D.C., Hynes, R.O. (2017) Intravital imaging of metastasis in adult Zebrafish. BMC cancer. 17:660
- Tang, Q., Iyer, S., Lobbardi, R., Moore, J.C., Chen, H., Lareau, C., Hebert, C., Shaw, M.L., Neftel, C., Suva, M.L., Ceol, C.J., Bernards, A., Aryee, M., Pinello, L., Drummond, I.A., Langenau, D.M. (2017) Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. The Journal of experimental medicine. 214(10):2875-2887
- Moore, J.C., Tang, Q., Yordán, N.T., Moore, F.E., Garcia, E.G., Lobbardi, R., Ramakrishnan, A., Marvin, D.L., Anselmo, A., Sadreyev, R.I., Langenau, D.M. (2016) Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc-null SCID zebrafish. The Journal of experimental medicine. 213(12):2575-2589
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