Genomic Feature
nl15
- ID
- ZDB-ALT-151222-3
- Name
- nl15
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nechiporuk Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 20: 54274548 (GRCz11) (1) Details
- Nucleotide change
- T/G
- Variant Notes
-
T to G mutation in the start site of actr10
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>G in Start Codon (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
GCATGGAACTTTCATATACCGTTAAAAACTTACATAATATTTAACATTAATATCTAGCAATTTTATAGAATGTTATTATTAATTATTATATATAATTTACTCAGGCGCTGTTGCTGTACGTGTCCCCCGCGTACTGATCTAGGTTCAGTTTTAATTAAGAAGAATTTTCCGCTTTCTATAAGTGTAACCGATGAAGAACTGATCTCAGATCAGCGGTGCATGTGACTTCAGCAGGACTCAATTCATTACATATAGAGCGCACATAAAATAAAACACAACATTACGATTATGTAAATTTGAAGAAACTGTTTTCGGATGAACTGCCTGATTTATAATCGCTGATATGACTACTATTTTATTCAGGCAGACGCAGGGCAGCCGCTGTAAAGGACCCAGCCGTTCCTCTAATGTTATGATTGTCGGCGCTGTGTTTGCTCAGTGATAATAGTAATTATAATAATCTGTTTGTCTCGAGTTTCTCTTAATTTCTGCTGATAAAA
T/G GCCCTTGTTTGAGGGCCTGGGCAGCGGAGGAGAAAAGACCGCGGTGGTGATTGATTTAGGAGCGGCCTACACGAAGTAAGTGATGATTGACAGCTTACAAACACACACAGATGACGAGAATCTCTATCTGGATTGATTAATGTTGAATATTGATTAGCCAGAAGATGAAGAGCATCTCTAACTCTTTATTTCGGTTATTAATGACGAACACAGTGCTTTCAGAAACACACAGTCGGTTATTTACTGTGGTTAACGTGCTAATGATGATCTAAATGTCATTAATAATACAGGGTTTCTGCCAAAATCCAAGTTTAAGACTCTTTTACGATCATCGTAAGTGAAAATATACAGGGCTAAATCACGCTATTTTTAATTGACCCATTAATAATGTGTTAGCCACATGTGTTAAACAGTGGCAAGGCTAGCAAACACTATTTGTAAAGATAGTGTACACTGTTTACAATGCTTCAATTAGTTTGAAAAGCTTTTAAAATGTAATA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| actr10nl15/nl15 | Homozygous | ♀+/- ♂+/- | 4 figures  from 2 publications | Fig. 6 from Herbert et al., 2017 | |
| actr10nl15 | Unknown | Unknown | |||
| actr10nl15/nl15; nl1Tg | Complex | 3 figures from Drerup et al., 2017 | 2 figures from Drerup et al., 2017 | ||
| actr10nl15/nl15; sl3Tg; vu19Tg | Complex | Fig. 3 from Herbert et al., 2017 | Fig. 3 from Herbert et al., 2017 | ||
| actr10nl15/nl15; vu16Tg | Complex | Fig. 4 from Herbert et al., 2017 | Fig. 4 from Herbert et al., 2017 | ||
| actr10nl15/nl15; vu19Tg | Complex | Fig. 3 from Herbert et al., 2017 | Fig. 3 from Herbert et al., 2017 | ||
| actr10nl15/+; actr10stl83/+; nl1Tg | Complex | Fig. 1 from Herbert et al., 2017 | Fig. 1 from Herbert et al., 2017 | ||
| actr10nl15/+; vu16Tg | Complex | Fig. 4 from Herbert et al., 2017 | |||
| actr10nl15/+; vu16Tg/+ | Complex |
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Supplemental Information
- Genotyping protocol
- None
- Kawano, D., Pinter, K., Chlebowski, M., Petralia, R.S., Wang, Y.X., Nechiporuk, A.V., Drerup, C.M. (2022) NudC regulated Lis1 stability is essential for the maintenance of dynamic microtubule ends in axon terminals. iScience. 25:105072105072
- Mandal, A., Wong, H.C., Pinter, K., Mosqueda, N., Beirl, A., Lomash, R.M., Won, S., Kindt, K.S., Drerup, C.M. (2020) Retrograde mitochondrial transport is essential for organelle distribution and health in zebrafish neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(7):1371-1392
- Drerup, C.M., Herbert, A.L., Monk, K.R., Nechiporuk, A.V. (2017) Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons. eLIFE. 6
- Herbert, A.L., Fu, M.M., Drerup, C.M., Gray, R.S., Harty, B.L., Ackerman, S.D., O'Reilly-Pol, T., Johnson, S.L., Nechiporuk, A.V., Barres, B.A., Monk, K.R. (2017) Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivo.. Proceedings of the National Academy of Sciences of the United States of America. 114:E9153-E9162
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