Genomic Feature
p172
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 15: 8779266 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A in Donor Splice Site of Intron 3 (1)
- Transcript Consequence
- Exon Loss of Exon 3 (1)
- Protein Consequence
- None
- Flanking Sequence
-
TGACTAATGTATTTTATTGTTTATTTTAAATATTTTTAAATTTTAAGTAGTGTGTAAAGGCTTCTCTTTAGGTTAAAAAGTTTGTTTCTAAATGGCCATGTTTACCTTATCTTCACTTTCTCCTAAGGGGATCCTCATTTTGGTTATATGGAGAGAAAATATAAAGCGTCCAAAATATTCAAATCATATTATGGCATGCTGAATCGATAGTGTCTGTAGTACCAGCTATTCAATTTCATCATTTATGATTCTAATCCTTATACGATTGTTAAAAACATCACACTTCATATCATTTTAAAGGCCTTAGACAGGATTTGTTTACATTTTGTGGTCAAATAGTGCCTATGTATTGGTCTTAAATATCATGTGCTATTTTTCCTCTGCAGTTCAGAAACTTCAAGATCATTTACAGGCGGTATGCTGGCCTGTACTTCTGCATCTGTGTGGATGTGACGGACAATAACCTGGCATACCTGGAAGCTATTCACAACTTCGTTGAG
G/A TAAATTTGACAAAAGCCAGCTTTAACTCTATTTATACTGTATATCTTTGAGATGCTTGATTCCAATTTTGCTGATAAACACACAGCTTAAGTTCTAGACAGACTTTTGAGCAAAGTTTGATATCACTTTACTGATTTCAGTTTTTTAAAATTTCAAACAGACAAATGTCTTGAAATACAGCATCTAAACCAGTGGTTCTCAAATAGTGGTATGTGTACCACTAGTGCAGTGATAGGCAAACTCGGTCCTGGAGGGCCAGTGTCCTGCATAGTTTAGCTGCAACACTAATCAAACACACCTGAACATGCTAATCAGCGTATGCAAGATCACTAGAAATCTTTAAACAGGTGTGTGTGTGATTAGAGTTGGAGCTAAACTGTGCAGGACACCGGCCCTCCAGGATCGAGTTTGCCCACCCCTGCACTAGTGGTACGCAGGCTTCCTTCTAGTGCAGGGGTGCCAGCCCTGTTCCTGGAGAGCCACCTTCCTGCAGATTTCAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| ap2s1p172/p172 | Homozygous | ♀+/- ♂+/- | 2 figures  from 2 publications | ||
| ap2s1p172/p172 | Homozygous | Unknown | 6 figures from Zúñiga Mouret et al., 2024 | ||
| ap2s1p172/+ | Heterozygous | Unknown | Fig. 1 from Zúñiga Mouret et al., 2024 | ||
| ap2s1p172/p172; hv2Tg/hv2Tg | Complex | Fig. 7 from Zúñiga Mouret et al., 2024 | |||
| ap2s1p172/p172; hv3Tg/hv3Tg | Complex | Fig. 8 from Zúñiga Mouret et al., 2024 | |||
| ap2s1p172/p172; casrp190/p190 | Complex | Fig. 6 from Jain et al., 2018 |
1 - 6 of 6
Show
Supplemental Information
- Genotyping protocol
- None
- Zúñiga Mouret, R., Greenbaum, J.P., Doll, H.M., Brody, E.M., Iacobucci, E.L., Roland, N.C., Simamora, R.C., Ruiz, I., Seymour, R., Ludwick, L., Krawitz, J.A., Groneberg, A.H., Marques, J.C., Laborde, A., Rajan, G., Del Bene, F., Orger, M.B., Jain, R.A. (2024) The adaptor protein 2 (AP2) complex modulates habituation and behavioral selection across multiple pathways and time windows. iScience. 27:109455109455
- Nelson, J.C., Shoenhard, H., Granato, M. (2023) Integration of cooperative and opposing molecular programs drives learning-associated behavioral plasticity. PLoS Genetics. 19:e1010650e1010650
- Jain, R.A., Wolman, M.A., Marsden, K.C., Nelson, J.C., Shoenhard, H., Echeverry, F.A., Szi, C., Bell, H., Skinner, J., Cobbs, E.N., Sawada, K., Zamora, A.D., Pereda, A.E., Granato, M. (2018) A Forward Genetic Screen in Zebrafish Identifies the G-Protein-Coupled Receptor CaSR as a Modulator of Sensorimotor Decision Making. Current biology : CB. 28(9):1357-1369.e5
- Wolman, M.A., Jain, R.A., Marsden, K.C., Bell, H., Skinner, J., Hayer, K.E., Hogenesch, J.B., Granato, M. (2015) A Genome-wide Screen Identifies PAPP-AA-Mediated IGFR Signaling as a Novel Regulator of Habituation Learning. Neuron. 85(6):1200-11
1 - 4 of 4
Show