Genomic Feature
dtk3
- ID
- ZDB-ALT-150312-7
- Name
- dtk3
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- Other Pages
Notes
| Comment | Citation |
|---|---|
| This is a dominant mutation that results in a I152F change in the protein ... | ZFIN Staff |
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 1: 47416387 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- A>T (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Ile>Phe at position 152 (1)
- Flanking Sequence
-
GTAGTCTTGTCCTCTGTGCCTTTCAGTGACCATGTTTGCAGAGTTCTGCTGGTGCGCCAGTCGGTCGTGAAATGGAGGGCAGGTCGGATGTAAAAGTGAGTGTGTCTGTAAAGTAGGAGAAGATGGCGGCGAGGTCAAGCATTGGTTGAAATCTGGAGGTGGGGTGCAGGCTCGGTTTGGGGTGGACGGATTTGGTGAAAGTGCAGGCATGGTGGACGGCGTGTTTGGTCGTTGTTTGGAAGCCTTGTATCCGTGCACATACTTCCTCAACTGCTTCCATGCCAAATGATACAGTTCCACGATACTAAGCAGCAGTGACACCGCTGCTACTGCTAGCATGAAGACAATGAACACGTTCTTCTCTGTTGGTCTGGAGATGTAGCAGTTGACCGGATGTGGACACGGAGGGGCTTTACACACATAGAGTGCACTAAGGAAGACTCCGTAGATCAGGTACTGGATTATGATGAAGATCACTTCCATCACAGTGCGGATGAGGA
T/A GCTGAGGACGTATGTTTGCAGCAACGCACCCTTCAATCGTACCCTCCTACCTCCACCTTCGTCCTCCTTGTTCTTGTCATCTTCTGGGTACTTTTCTCCATCTCTCTGCGCTCCTTCATCATCCAGCTCTTTCCTCTTCTTCTCCTCTCGGCGGACGATATGCATTGCGTGCCCCATGTAGATCAGAGAAGGTGTAGACACGAACACGATCTGGAGCACCCAGAAGCGTATATGCGCTATAGGAAAGGCTCGGTCGTAACAAACGTTCTCGCAGCCGGGCTGCTCTGTGTCGCAGGTGAAGTCTTCCTGCTCGTCCCCCCACGAGGATTCAGCAGCCGTGCCTAGTACCAAGATCCGGAAGATGAAAAGAATAGTGAGCCACACCTTTCCCACCGAGGTTGAATGCTCCTGGACTTCTTCTAGAAAGTTCCCCAGCAGACTCCAGTCGGCCATGCCTATTCAGAGGAGCCTGAGGTGGAAATAAGAGGTAGTGTGAATGG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| gja5bdtk3/dtk3 | Homozygous | ♀+/- ♂+/- | 2 figures  from Irion et al., 2014 | ||
| gja5bdtk3/+ | Heterozygous | Unknown | Fig. 1 from Irion et al., 2014 | ||
| gja5bdtk3/+; gja5bt1/+ | Complex | Fig. 1 from Irion et al., 2014 | |||
| csf1ratm236b/tm236b; gja5bdtk3/dtk3 | Complex | Fig. 5 from Irion et al., 2014 | |||
| gja5bdtk3/dtk3; ltkj9s1/j9s1 | Complex | Fig. 5 from Irion et al., 2014 | |||
| gja5bdtk3/dtk3; mitfaw2/w2 | Complex | Fig. 5 from Irion et al., 2014 |
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Supplemental Information
- Genotyping protocol
- None
- Mahalwar, P., Singh, A.P., Fadeev, A., Nüsslein-Volhard, C., Irion, U. (2016) Heterotypic interactions regulate cell shape and density during color pattern formation in zebrafish. Biology Open. 5(11):1680-1690
- Irion, U., Frohnhöfer, H.G., Krauss, J., Çolak Champollion, T., Maischein, H., Geiger-Rudolph, S., Weiler, C., Nüsslein-Volhard, C. (2014) Gap junctions composed of connexions 41.8 and 39.4 are essential for colour pattern formation in zebrafish. eLIFE. 4:1225-38
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