Genomic Feature
biu4
- ID
- ZDB-ALT-150122-1
- Name
- biu4
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with zinc finger nuclease
- Lab of Origin
- Appelbaum Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 14: 1098414 - 1098420 (GRCz11) (1) Details
- Nucleotide change
- GGGTGAG/-
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 7 bp deleted in Exon 1 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: at position 97 (1)
- Flanking Sequence
-
CAAACTTTACCTCAGTTTCTAAGTTCAACTCAAAATAACAACATTCTAGTCTGTGATGACATTAAAGAAAAAAACACAATAGTATATTTATAGCAGGTGTTTGAGCGCGTGTGAATCCTGCTGGTGGCCGTGGAGCAAGAGATGCGAGTGGGCGGCTGCTGGGTCAGAGTGTGGCGGCTCAGAGAGCAGCTCCGGGCGGCTCCAGCAGACGCAGAGCCTCGTATGATCAGCTGTGATCCCTTAAGCCTTCAATCTCCCTTCAGCTCACACTAACAGCACTTCAAATCTCACACTCCAGCACTTACTGAACAGATGGAAGATTCGACTCACCCACTTTAAACTGAGACGCCTGGTCCGGCTGCTTCTCGTGGTGCTTCACCAGCATCATGTGCAGAATCCCGAATGAGTTCTGGATGCCGAAAATCGAGCCGTTGCACCATGTAGCAGCGAACACCACGACCCAACCGAAGCCCCCCTCCGGGGGAACGAAGCCTTGTCCA
GGGTGAG/- CGCCAGGCGGCGTGGCCGGACGCTTGTCAGTGCAGCCGGTGTGTATGAGCTGCACGGTGCTGTCCTCCGGGGCCAGCTTGCGCTCCTGCTCCTCGAACTCCTCCGCAGGGGAAGAGGACTCCTCAGCCTGCGGGTCCTCCGAGCCGGGCGTCCCACCAGCCGTGTTGTCATCGCTTTCCGAGTGCATCCTACAGGGAGAGGATGCAGACGCGTTTCCCCGAGAACTACTTTATAACATGCAAGTGAGGGAGAAAAAAAAGAACAAAAATAAATCCCTTCAGGAATTTCGCAGAGAACTAAGTCAATCTCGCGTCACTTTGCACGGATGATCACTCATAATCCTCCCGATAATGCCCAAATCCTGTTATGAGAGATCACTCTTCATAATAAAGCTGCAGGACTTCAAGCAAACGTTCTCTGAGGTGAAAACTGAGAGCGCGCGCGCGCTTTAAACCGACTCCAAAACTCTGCTCTCGGTCCACATCCTTTTTATCGTGCAC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| slc16a2biu4/biu4 | Homozygous | ♀+/- ♂+/- | 5 figures  from Zada et al., 2014 | 5 figures from 3 publications | |
| slc16a2biu4/biu4; biu3Tg; biu5Tg | Complex | Fig. 6 from Zada et al., 2014 | Fig. 6 from Zada et al., 2014 | ||
| slc16a2biu4/biu4; ck1Tg | Complex | 4 figures from Zada et al., 2016 | 2 figures from Zada et al., 2016 | ||
| slc16a2biu4/biu4; mde4Tg; mde6Tg | Complex | Fig. 6 from Zada et al., 2014 | |||
| slc16a2biu4/biu4; slco1c1biu16/biu16 | Complex | 2 figures from Admati et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Rozenblat, R., Tovin, A., Zada, D., Lebenthal-Loinger, I., Lerer-Goldshtein, T., Appelbaum, L. (2022) Genetic and Neurological Deficiencies in the Visual System of mct8 Mutant Zebrafish. International Journal of Molecular Sciences. 23(5):
- Wasserman-Bartov, T., Admati, I., Lebenthal-Loinger, I., Sharabany, J., Lerer-Goldshtein, T., Appelbaum, L. (2022) Tsh induces Agrp1 neuron proliferation in Oatp1c1 deficient zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 42(44):8214-8224
- Admati, I., Wasserman-Bartov, T., Tovin, A., Rozenblat, R., Blitz, E., Zada, D., Lerer-Goldshtein, T., Appelbaum, L. (2019) Neural alterations and hyperactivity of the hypothalamic-pituitary-thyroid axis in Oatp1c1-deficiency. Thyroid : official journal of the American Thyroid Association. 30(1):161-174
- Zada, D., Tovin, A., Lerer-Goldshtein, T., Appelbaum, L. (2016) Pharmacological and BBB-targeted genetic therapies for thyroid hormone-dependent hypomyelination. Disease models & mechanisms. 9(11):1339-1348
- Zada, D., Tovin, A., Lerer-Goldshtein, T., Vatine, G.D., Appelbaum, L. (2014) Altered Behavioral Performance and Live Imaging of Circuit-Specific Neural Deficiencies in a Zebrafish Model for Psychomotor Retardation. PLoS Genetics. 10:e1004615
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