Genomic Feature
ha2
- ID
- ZDB-ALT-121012-1
- Name
- ha2
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Kikuchi Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 8: 16258780 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A at position 262 (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Cys>Ser (1)
- Flanking Sequence
-
TTATATAAAACATATGTTCAATTGTACTTTAAAGGGAATTATGTTCTTAAACTGGCTATAACATGATAATTTAGCTCTCTAAAAAGCTGGAATATTGTGTGCTCTTTTTTTCAACATATACTGGATTCTGTAACAAGTTGCATTAAATAATGCCAGTACAAATATATATTTTTATTAATACTATCTTCGTTATAATATGGAAAACTAAAAGGTGGATCACACTTACTGCTTCCAACTAAAATCTTTATTTTTAAGTATTTCCATATAGGCTATATGATCATAACGTTTCTACTTACCAGAGTTTGATTCGTTGCTAACTGGGCCGAAGACCTCGTAGTTTTGCCGGGGAGGTATGATGCCGTTGGCAGCGGCAAGGGCCAGACCCTCTGCTGTGCCGTAGAGCAGCTGGAGCTCTCTCGCCTCGTTCTCCTCCTGCGCCTGCTGTCTGCGGAGCGCGACCTGAGCGGCCATCACGCGCTGTCTCTCCGCGATCAGGGTGC
A/T TTTGGCACACATACAGTCTTTCCATCTGCAGTAGCGCTTATGCCCCTTGAGCGCGGATACCACGCCGTGATTCCTGCACCGGGCGCACTTGGGCGTCCTTGGATACTTCTCCGTAGCGCGAAGCAACAGCGGCGGGGCCCTTAACAGGCTACCTGCCATTGAAACTGGTATGGAGGCGGCAGCGGCCGCCGCAGCAGCAGCGCCTGGATGAACCTGCGACCCTGCCTGAGAGGCGGGTGGGATCTCTGGACGAAGATCCATATTCTCCGAATCAACAAACAGCGGATCGATAGGTTAAAATACGTGCGCAACCGAAGTCTTCGATCGGAGACGTTTCATAAGCATTGGCCAGAATCGATACAAGGTGAATATCTTCAGTACAGCATTTAAAGAACACAGCCCGACTGCCAGTGTCCAAGAAGAAAGCAGAAACCAATTTATTATGAAAGTCCTCTTTCCAGCGAGATCTTCAACTTGTTGCGCACAGTCCACAAGCAGCC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| dmrta2ha2/ha2 | Homozygous | ♀+/- ♂+/- | 8 figures from 2 publications | 8 figures from 2 publications | |
| dmrta2ha2/+ | Heterozygous | ♀+/- ♂+/- | 4 figures from 2 publications | 7 figures from 2 publications | |
| dmrta2ha2/ha2 + MO1-her6 | Complex | Fig. 8 from Yoshizawa et al., 2011 | Fig. 8 from Yoshizawa et al., 2011 | ||
| dmrta2ha2/+ + MO1-her6 | Complex | Fig. 8 from Yoshizawa et al., 2011 | |||
| dmrta2ha2/ha2 + MO4-tp53 | Complex | Fig. 8 from Graf et al., 2015 | Fig. 8 from Graf et al., 2015 | ||
| dmrta2ha2/+ + MO4-tp53 | Complex | Fig. 8 from Graf et al., 2015 | Fig. 8 from Graf et al., 2015 |
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Supplemental Information
- Genotyping protocol
- None
- Graf, M., Teo Qi-Wen, E.R., Viktor Sarusie, M., Rajaei, F., Winkler, C. (2015) Dmrt5 controls corticotrope and gonadotrope differentiation in the zebrafish pituitary. Molecular endocrinology (Baltimore, Md.). 29(2):187-99
- Yoshizawa, A., Nakahara, Y., Izawa, T., Ishitani, T., Tsutsumi, M., Kuroiwa, A., Itoh, M., and Kikuchi, Y. (2011) Zebrafish Dmrta2 regulates neurogenesis in the telencephalon. Genes to cells : devoted to molecular & cellular mechanisms. 16(11):1097-1109
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