Genomic Feature
st67
- ID
- ZDB-ALT-120726-2
- Name
- st67
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Talbot Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 20: 32516189 (GRCz11) (1) Details
- Nucleotide change
- T/G
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>G (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Tyr>Asp at position 647 (1)
- Flanking Sequence
-
AAAAATAAAAGATTTGTTCATTTTGATTTCAGCCCTACTTGTTACTTGGAAAGTAATATTATTACAATATATCTTTGTGTAATTTATACATTTTTTGTGTGTGTGTGATGCTCATGTTTTGCAATATTATTTTTCTTCACAGGAAGTTGTGTCAAAAGAAGAAGAGGAAGATCTGTCTGACAAAGGCAGCGAATCAGACGAAGCAGAGGGAAATAAGGACTCACCCAGTGAAAGAGATGATGAGAGCGACAAGCAGAGCGACACTGAAGGGGATGAGATCGCCAGAGATGACGAGGAGGTGTGTGTATGTGTTATCTCTTGGAAGAATGTCTGCTGATGTGCAGCTTTTCATAACTAGAGCATCTTTTCTGTAGGAATGGGAGGCTCTACAGCAAAGCATTCAGCGGCGTGAACGAGCACTGTTGGAGACCAAGTCTAAGGTCACTCATCCAGTCTACAGTCTGTTCTTCCCTGAGGAGAAGCAGGAGTGGTGGTGGCTC
T/G ACATCGCAGACCGGAAGGAACAGACACTGGTGTCCATGCCCAACCACGTGTGCACACTCAAAGACACAGAGGAGGTGAGCGCTTTACTAAGAACCGATGACAGAGTGACCTTGTGTAAACCATGCAGTGTTGTTCGAGGTATTTGGATTTTAATAAAAAGTTGAATTCGATTTAAAGAGATTATTTAGCTGACATTTTACATTTTTATTGACTTTCCGCTTAGGTACTTCAAACTTGTAAGAGTTTCTTCTGTTGCACGTAAAAAAAGATGTTTTGAAGAATGTTGGTTACTAAGAGGTTGCTGTATTCAATTTCTTTCATGGTAGGGAAAACAAAGCTATGAAAGATAGGTTTGATTACCAGTATTGTGGTTATCTATGGGTTTATAAATCCGTCGATTGTTTGAGCTGTCTTCCAGTGTATTGTATCATTCTTTCTAGCTATTGTTCTCTCTATCGTAATCATCCAGCCCTAGTACAAAGATAGATAGATAGACAGAC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| sec63st67/st67 | Homozygous | ♀+/- ♂+/- | 8 figures  from Monk et al., 2013 | Fig. 5 from Monk et al., 2013 | |
| sec63st67/+ (AB) | Heterozygous | ♀+/- ♂+/- | |||
| sec63st67 | Unknown | Unknown |
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Supplemental Information
- Genotyping protocol
- None
- Asaoka, Y., Terai, S., Sakaida, I., and Nishina, H. (2013) The expanding role of fish models in understanding non-alcoholic fatty liver disease. Disease models & mechanisms. 6(4):905-914
- Monk, K.R., Voas, M.G., Franzini-Armstrong, C., Hakkinen, I.S., and Talbot, W.S. (2013) Mutation of sec63 in zebrafish causes defects in myelinated axons and liver pathology. Disease models & mechanisms. 6(1):135-145
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