Genomic Feature
sa1349
- ID
- ZDB-ALT-120411-117
- Name
- sa1349
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation
- Protocol
- adult males treated with ENU
- Lab of Origin
- Stemple Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 20: 23888386 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- at position 4597 (1)
- Flanking Sequence
-
TGCCTTCAGGGGGGAATCAAGCGGTAGTAGGGGGGTCAATCCCCCCAAACCCCCATGTAATCCGCACCCTTGTTTTCCATTTAGGATGTTACAGCAATACTACAAATTTGAAGCAATAAAAGGATTGTAAATCAAATTTAAAATTAAAAAAACTATATCTATACCAACACATTTAAAGACGAACATCTGCAAAAAAATATGACCTTTAAACTGTTTTACTTTTGAACACTGCAATAAAATATTGATTGAACATTTTTTTTCTTAATCGTTTTAATTCACAGACAGTGATCTCTGGCATGACATATAGGCGATGTAGATTACAATTGACCAAAATGAGAAAGAAACAGGTAGTAACAACCGAAATTTGAGCAACTCTGTCTGTAGTAAGCAGTGCAAGCAGGCAGAGCAACATCTACCTTTTGTGCAAGTTCAGTGAAGACATTAGCGAGGACGGACAAAAGCTTTCCGGTGGTACGGTGAGCCCCCATCAGCACAGCAAG
A/T TAATACCTCACCAATTCAGAGTAGAGACACAGCATGGGCTCCAAACGCACCACACTCCTGCAAGCCTCTCTCAATTCCTTTATATAAAACAACACACATTTTAACTGATATTTTCAGACAGTAACCATTTGGGTATAATATTTAATGTATATTTAATGCATGACTGACCTGTAAATGGTGAGGCTGACAGTCGTCCCTGTGTGAACGAAGTCTCTCCAGCAGCTCTGTTACGACTCCATTGATCTCGGGTAATGAGAGACTGGACAAGTCTCCACTCAGTTCCTCTTCCAGCAACCTGCTCAAGTGTCCTGGTTTTAAGAGCTCCTCCACTACCTCTGAGTCACTCTCTATAAAAAAACATAAATGAGCTCTCATATATACACAAATATATCTCCTAAAACATGCCGTATGCAAATTCATGGCTGATTTTGCACCTCTCTTGCTTTCTGACAGCTGATCCTCCTGCTTTTCCTTCTCCTTCCTCTTAACTACTGTCTGAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| mdn1sa1349/sa1349 (TL) | Homozygous | ♀+/- ♂+/- | 2 figures  from 2 publications | ||
| mdn1sa1349/+; mdn1sa6631/+ (TL) | Complex | Fig. 4 from Kettleborough et al., 2013 |
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Supplemental Information
- Genotyping protocol
- None
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- Collins, J.E., Wali, N., Sealy, I.M., Morris, J.A., White, R.J., Leonard, S.R., Jackson, D.K., Jones, M.C., Smerdon, N.C., Zamora, J., Dooley, C.M., Carruthers, S.N., Barrett, J.C., Stemple, D.L., Busch-Nentwich, E.M. (2015) High-throughput and quantitative genome-wide messenger RNA sequencing for molecular phenotyping. BMC Genomics. 16:578
- Kettleborough, R.N., Busch-Nentwich, E.M., Harvey, S.A., Dooley, C.M., de Bruijn, E., van Eeden, F., Sealy, I., White, R.J., Herd, C., Nijman, I.J., Fényes, F., Mehroke, S., Scahill, C., Gibbons, R., Wali, N., Carruthers, S., Hall, A., Yen, J., Cuppen, E., and Stemple, D.L. (2013) A systematic genome-wide analysis of zebrafish protein-coding gene function. Nature. 496(7446):494-7
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