Genomic Feature
t31954
- ID
- ZDB-ALT-110523-9
- Name
- t31954
- Synonyms
-
- SD008PMA (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The T-to-A transversion in this allele leads to a change from a highly ... | Lobbardi et al., 2011 |
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 17: 27783650 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Ile>Asn at position 156 (1)
- Flanking Sequence
-
ATAAATAAATTGTAGCCTTTTTACCAACAGGTTCATTACACAAACCCAGCTATCTACGAAACTATGTTAACTATATTAAGTGCTATTAATTTGACCATTTTTTGAGAGGATGCATTTGACAGATTTGCAGAGTTTCCACACTGTTAGTGGAAATCCAACTAATTACCAGAATTAAACATTTTTTTAACTATTTTCTGTTGAGATAACATGCGGCAGCTAACTGACTAATTGTAAATGTGGTGGTAAATATTCTACTCCGATTCCCAGTGCATGTTAATGTGAAGAACAACCATCTTTAACTCACTGTGAGGCTGCTTCAGCGTGCCGGCTGTCACAAAAAATGTTGCACTTTTTCACACCGACTCGAAGTTTAATAATCTGTAAGAAGTCTGTCACTGCCAACACATCTCTCACTCTCTCTCGTTTTCTGTTTTTTTAGGAGGAACAGAACAGAGGGAAGCCAAACTGGGAGCACCTAAATGAAGATTTGCATGTACTGA
T/A CACAGTGGAGGACACACAGACACGTGCTGAGATCAAGATGAGAAGAGCTGTCGAAGAGGTCAAGAAACTACTGGTGCCTGCAGTAAGTTGCACATGTTTGTTCTTCCCAAATATACTTGCGGTTTGAAAGTGATGCTACAAATGTTTTGACCTTTGAGATCCTCTCCTCAGACCTGCTTGAGGCTTGTACTTTGATGTAAGGCAGCACTGTTGAATCTGGCAAAACATTCTATCCTGCTTCCTGTTCTAGGTGTGATGCCTTTGTGCATATGGGGCGGATTTTAATCCCACCCCTGACCCCTGGCTTCAGTCTTCTGCTAGATTTGATATTTTTATCTCTGGCTCCCAACAGAGAACAAATGGTGCTCTGCAACCTGATTCCCACAGATTTCCGCCCCATTCCACCTTTCTGTTCTCTGCTCCTCCATCGGTTGCTGCAGGGGGTGCGGACGCTTAAGTCAGGGTCTTGGGCTCCAGGCTGTTTTGCCTGCAGTGAACAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| qkiat31954/t31954 | Homozygous | ♀+/- ♂+/- | 5 figures  from 2 publications | 3 figures from Lobbardi et al., 2011 | |
| qkiat31954/+ | Heterozygous | ♀+/- ♂+/- | Fig. 4 from Bonnet et al., 2017 | ||
| qkiat31954/+; qki2zf1088/zf1088 | Complex | Fig. 4 from Bonnet et al., 2017 | |||
| qkiat31954/t31954; i104Tg + MO1-qki2 | Complex | Fig. 2 from Bonnet et al., 2017 | Fig. 2 from Bonnet et al., 2017 | ||
| qkiat31954/t31954 + MO1-qki2 | Complex | 3 figures from Bonnet et al., 2017 | Fig. 4 from Bonnet et al., 2017 | ||
| qkiat31954/t31954; qki2zf1088/zf1088 | Complex | ||||
| qkiat31954/t31954; qki2zf1088/zf1088 | Complex | Fig. 4 from Bonnet et al., 2017 | Fig. 4 from Bonnet et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- Bonnet, A., Lambert, G., Ernest, S., Dutrieux, F.X., Coulpier, F., Lemoine, S., Lobbardi, R., Rosa, F.M. (2017) Quaking RNA-Binding Proteins Control Early Myofibril Formation by Modulating Tropomyosin. Developmental Cell. 42(5):527-541.e4
- Lobbardi, R., Lambert, G., Zhao, J., Geisler, R., Kim, H.R., and Rosa, F.M. (2011) Fine-tuning of Hh signaling by the RNA-binding protein Quaking to control muscle development. Development (Cambridge, England). 138(9):1783-1794
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