Genomic Feature
sa140
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 9: 2004100 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
TGTTCAGTAATATTTTAGTGTTGCATTTTTCCTAATGTCTGAGTGCTAGCATGTCGATGCATTTATCGAAATAAATTGTCTGTCGTTGCATTATGTAGTGTACACATTTAGCGTTTTAAAAAAAATATATATGCAAACGTTTGCATTTAATTGTGTATATGTAATTGCATTTTATTTTTTCCTTTAGATCTTTCGTTTATTCAAAATATTTTACACTGAATCTCTGAGTAAAAAAAATGTAATGCGATCCCAAAACGTTCCCGTTTAATTTAACTTATTTTACAAATGCATGATTTTCTTTGTTCATTATTTTAATGTTCAAATTAATGTGTTTTTTACCTCAAAATATATTTGTAAAATATTTATACATTTGAATTGTATCTCTTTCGTTATCCGATTTAGGTTTCTCGGACAGCAATTCAGGAGGCTCCAATACAAGTTCATCCTCTCTATCGAATCTTAACGGTAATTCCATGGGAAACAGCAGCTCGAGCTCGGAC
C/T AGGTGAGGAGGTACCGGACTGCTTTTACCCGAGAGCAGATTGGAAGACTGGAGAAAGAATTTTACAGGGAAAACTACGTCTCGAGACCCAGGAGATGTGAATTAGCCGCAGCATTAAACCTGCCCGAAACAACAATAAAGGTAATGCTCTGATTTTGTTCACCAGGATATAATTTGTACCTGCTAATTTATAATGTTTAGCAAACAAATATTAACTGGTTACATGCTCTAGCACTATAAATTCACGCATTTAAATGCCCATTGCCAAATCTAAAATAATAATCCATTCTGTTATATATATATATATATATATATATATATATATATATATATATATATATATATATAAAGAATATTTCTATATAGTGGACATAAATAATGCAGGGATGTAGCTAAAGCACTGTGTAATACAGACAATTTTATTTTGTCTGATGCAGAACCCCGTCTTTTTCATCTGAGCTCTCCTAAGATATTAAAATTAGTTGCATTTGCAAAACTATT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| evx2sa140/sa140 | Homozygous | ♀+/- ♂+/- | 2 figures  from Juárez-Morales et al., 2016 | 3 figures from Juárez-Morales et al., 2016 | |
| evx2sa140 | Unknown | Unknown | |||
| evx1i232/i232; evx2sa140/sa140 | Complex | 4 figures from 2 publications | 6 figures from 2 publications | ||
| evx1i232/i232; evx2sa140/sa140; su1Tg | Complex | Fig. 5 from Juárez-Morales et al., 2016 | 2 figures from Juárez-Morales et al., 2016 | ||
| evx1i232/i232; evx2sa140/sa140; su2Tg | Complex | Fig. 4 from Juárez-Morales et al., 2016 | Fig. 4 from Juárez-Morales et al., 2016 |
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Supplemental Information
- Genotyping protocol
- None
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Hilinski, W.C., Bostrom, J.R., England, S.J., Juárez-Morales, J.L., de Jager, S., Armant, O., Legradi, J., Strähle, U., Link, B.A., Lewis, K.E. (2016) Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons. Neural Development. 11:16
- Juárez-Morales, J.L., Schulte, C.J., Pezoa, S.A., Vallejo, G.K., Hilinski, W.C., England, S.J., de Jager, S., Lewis, K.E. (2016) Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism. Neural Development. 11:5
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