Genomic Feature
la1186
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 18: 39297971 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
-
la1186 represents a C to T transition, producing a premature stop codon.
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
CGTTAGTCCGGGTTAGCATTGTATAACGGCTAGACTATCTTGGTGTATGCCCAGAGCTCTGAATATCGAATTATTCATTTGTATTCAATAAATTACTAATCTTTTAAGCATTTAACATTTTCTCCTGAGTTTGAATTGAACACGCATGAAATAGAGATAGATATTCCAACAATCGCAATGTTAGCTTTTTCCAATATCATGCAGCCCTACTTTGAAGTCCTTTAGTTTGTGTGTTTGTTCACATATAAAACCTTTATACCGAAAATAAACACAAGACAATGAATTAGAAAAAACCCTTTTGTAGATAAGGCTGCTGAAAAAGCTGGCGGTCACAATCGTGCATATGATATCACAACCATTACATTCTTTATTTCCCAATAATTGGTCTGTTTGGACCGAAAGTTTCACCTCATCGCTGTCCAGTCTCTTGGCCTTCATCAGTCGCTGGGCCTTGTCTTCATCAGAACCTTCATCGCTGTCTGACGAATAGATCCTGGCTC
G/A TTCCTCTATGACCCACAAACAAACAAAACAACATTTAAGCACAGCTCAGAATTCAGCACTCCTTTCCAAGCATTCCAGAGAGATGTTCTTTCAGTAAATAAATACCTCTTACTGGCACAAACAAATCAAACTGAGCAAACTAATCTAAATCTCAGTCGGACTCCGGCATAATGCAGTATTAAGGAGCCGGCAGGTAATCGGCTAACGGGCTGTAACAGTTACTGTCAGCGAGAAAGTGTGTGCGTGAGACGTGCTGTTTTGGGAACACAAGCTGTTGTTGAAGGGCAGAATGTTCTGGCTGATCGCAGCAGGTCCCAACCTCACTCAAAGAAATCCGTTGTGCAGAAACATTGACCCAAGAGGGAGAGAGGGAATACAAAATAAACGACAGACACAGCACCCCACCGCCGTTCAGAGGCCATTTCGACTGACCTACTTCATGTAGAGACCATCCTTTTTGTGTTTATCATCACAGCTATTAGTGCAGATGAGGTTTGGAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| leo1la1186/la1186 | Homozygous | ♀+/- ♂+/- | 5 figures  from Nguyen et al., 2010 | 7 figures from 2 publications |
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Supplemental Information
- Genotyping protocol
- None
- Jurynec, M.J., Bai, X., Bisgrove, B.W., Jackson, H., Nechiporuk, A., Palu, R.A.S., Grunwald, H.A., Su, Y.C., Hoshijima, K., Yost, H.J., Zon, L.I., Grunwald, D.J. (2019) The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Development (Cambridge, England). 146(24):
- Rasmussen, J.P., Sack, G.S., Martin, S.M., Sagasti, A. (2015) Vertebrate epidermal cells are broad-specificity phagocytes that clear sensory axon debris. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:559-70
- Villegas, R., Martin, S.M., O'Donnell, K., Carrillo, S., Sagasti, A., and Allende, M.L. (2012) Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types. Neural Development. 7(1):19
- Nguyen, C.T., Langenbacher, A., Hsieh, M., and Chen, J.N. (2010) The Paf1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish. Developmental Biology. 341(1):167-175
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