Genomic Feature
hu1864
- ID
- ZDB-ALT-080910-1
- Name
- hu1864
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- den Hertog Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 17: 23668504 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
AAAGAGACCATAAAAAGTAGTCTTTTTAACACTAGTTTCAGAATTAGACACTGTTAAAATGAAGTAGGGGTTGTACTCACCTCTACAGTTGAATTTAGATGCATCGTAGTGTCGTTCAGCACATCTAAAAAAGAAAATCAGGAGAGTTAAACTCCGAACAAACAATTTATGTTTGGTATGTCATTACTCAAATATAATTAAATACTTACAGATTATAAATTTTATAATGATTCTTATGCTTGGAATCTAAAAACCTGAAAGACAAAAAAATTAAGAAAGACAGAAGTTACAATTTTGAATTTCAACAAGCTATTAGATGAAACAACTGACTAACATTTGTTAGTGACTATTCATTCAAAAAAAAATGCATAATTTGTCAAATTTACGGTGAGACGAAATAAAAATAAATAAATAAATAAAAAAAAAAAGAATTGTGTGTTTTACCACGTTGACTTACCGGACAACGTCATCAATGTTGTTTCGGTAAACACCTTCCAATC
G/A TTCGGCTGGAAAGCCCATGGCAATGATGTTAGGGTATATGTCTGACATGTGTGTTAAAGAAAAAGATCATATGTGCACTGTACACCAGGTTAACATTAAGCAAAATAAACAATAAAATTAAATCTACAAGATGTTACTACATACATTCAACAATCTAAACAAGAAACTAGCGCTGCGTCTTATTAAAACATTATCATCGTAACAATAGTAATAAATGAAATATGTCTCACAGAATGGTGCAATAAAAATATTTTATGTGCCAAATATTTATGTGCTAAAAGCATAGGTTGTTAACCCAAATTTGAGTAATCAACCGGGACCTTACTTTCTGTGCACCTGCCTCCCCAGTAGGTTTTACAATGCTACTGGCTAGAGCAGGCCCAAAAGTAAAGCTATAGTGCCTTAGAGCAGAGCTGAAAATAAATACTGATTGTGAGAGAAGAGACAAGCAAGAAAAATGACAACAGTGAATAAAAATTTTAAAATCAGCAGAGGCATTC - Additional Sequence
- None
Fish
from 2 publications1 - 10 of 13
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Supplemental Information
- Genotyping protocol
- None
- Blokzijl-Franke, S., Ponsioen, B., Schulte-Merker, S., Herbomel, P., Kissa, K., Choorapoikayil, S., den Hertog, J. (2021) Phosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells. Oncogene. 40(15):2741-2755
- He, S., Zimmerman, M.W., Layden, H.M., Berezovskaya, A., Etchin, J., Martel, M.W., Thurston, G., Jing, C.B., van Rooijen, E., Kaufman, C.K., Rodig, S.J., Zon, L.I., Patton, E.E., Mansour, M.R., Look, A.T. (2021) Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene. 40(38):5718-5729
- Jung, K., Kim, M., So, J., Lee, S.H., Ko, S., Shin, D. (2020) Farnesoid X receptor activation impairs liver progenitor cell-mediated liver regeneration via the PTEN-PI3K-AKT-mTOR axis in zebrafish. Hepatology (Baltimore, Md.). 74(1):397-410
- Pereiro, P., Figueras, A., Novoa, B. (2020) Zebrafish pten Genes Play Relevant but Distinct Roles in Antiviral Immunity. Vaccines. 8(2):
- Ciarlo, C., Kaufman, C.K., Kinikoglu, B., Michael, J., Yang, S., D Amato, C., Blokzijl-Franke, S., den Hertog, J., Schlaeger, T.M., Zhou, Y., Liao, E., Zon, L.I. (2017) A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. eLIFE. 6
- Hale, A.J., Kiai, A., Sikkens, J., den Hertog, J. (2017) Impaired caudal fin-fold regeneration in zebrafish deficient for the tumor suppressor Pten. Regeneration (Oxford, England). 4:217-226
- Wild, R., Klems, A., Takamiya, M., Hayashi, Y., Strähle, U., Ando, K., Mochizuki, N., van Impel, A., Schulte-Merker, S., Krueger, J., Preau, L., le Noble, F. (2017) Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization. Nature communications. 8:13991
- Stumpf, M., Blokzijl-Franke, S., den Hertog, J. (2016) Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis. PLoS One. 11:e0154771
- Stumpf, M., den Hertog, J. (2016) Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development. PLoS One. 11:e0148508
- Choorapoikayil, S., Kers, R., Herbomel, P., Kissa, K., and den Hertog, J. (2014) Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish. Blood.
1 - 10 of 17
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