Genomic Feature
s904
- ID
- ZDB-ALT-080808-1
- Name
- s904
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Stainier Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 3: 54600854 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
GTTGAATGACATTTAGCCTCATTCAAAATGTTAATCATTATAATATAAAAACAGAGAAAGCAAAGAAAGGCCTTTAAAACACATGGAAAATACAAAACTGCTGAGGAGAATGATTACGCAACAGCAAAGACTGCACAGTAAGCATACCTCCTCTTCTGACAGGCTTGTTTACTTCTGCCACTGCCTCCAAACTTGATCATATCCTTACAAGCTGAACACTTGCCGCAGTCTGGAGCTTGACACACCTGAAATACCAAGGTCGCCAATCATCATGCTTGCATTTCAGTTAAACTGTGCCTGCTATTTTCAGACAACCAACCTCACAGACACCACACCGTTGTCTCTTCACACCTCCATCCTTATTGTTCTGGTCAATCTGATCAGAGAAGAATGTGTCAAAGATCAGGTAGACCAGTTTAGTGGTGGTGGCTTTAGTCGGGCCCTTGTTGTCCTTTTCAATCTTAGTGGGATGGCGGACGGCTTGTCTTCTGGCTGCTCTC
C/T TGAACAGGGGAAAAAAAAAAAACATGAGCAGAGCAAACAAGATACAGAGGGCACAAATAAAAGCAAAAAAGAGCCATGCGTTTAATGCACAAGACACAATGGATTGAGTTAAGACAAACAGCTCTGAAGTAACTAAACCCATTTAAACTGAAAAAAGATGTTCAGATTTCCCAAATGGACAACTTAAACAACAGGGTGCCAAATTAACATCTGTTATGCAGATCATGCAAGTCAGGAAGGTTTAAAAAAAATAAATAAACAAGTTCTCATGTTTTTGTTCTCCTCACCCACCCATTTCAGCTAATGAAGCAGTTTACCACCAACACAGGCGACTGCAGTTCAGCATATGGAAATATAAATAACCAAGCCACACACTCTGCAGAAACATCAGGATTTACATACCAGTACAGCTGCCTGCTGCATTAGAGAAAGTTAAAGGACCATTAGAAACAAATAACATGGTACCACAACTAAACCTCAAAATCTTAAGTCACTGAATT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| dnmt1s904/s904 | Homozygous | ♀+/- ♂+/- | 4 figures  from 3 publications | ||
| dnmt1s904/s904 (TL) | Homozygous | ♀+/- ♂+/- | Fig. 3 from Anderson et al., 2009 | ||
| dnmt1s904/s904; gz15Tg | Complex | 2 figures from Anderson et al., 2009 | 3 figures from Anderson et al., 2009 | ||
| dnmt1s904/s904; jh1Tg; m1018Tg | Complex | Fig. 5 from Anderson et al., 2009 | Fig. 5 from Anderson et al., 2009 | ||
| dnmt1s904/s904; mss4Tg | Complex | ||||
| dnmt1s904/s904; w37Tg | Complex | Fig. 6 from Ganz et al., 2019 | |||
| dnmt1s904/s904; uhrf1b1115/b1115 | Complex | Fig. 7 from Ganz et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Madakashira, B.P., Magnani, E., Ranjan, S., Sadler, K.C. (2024) DNA hypomethylation activates Cdk4/6 and Atr to induce DNA replication and cell cycle arrest to constrain liver outgrowth in zebrafish. Nucleic acids research. 52(6):3069-3087
- Madakashira, B.P., Zhang, C., Macchi, F., Magnani, E., Sadler, K.C. (2021) Nuclear Organization during Hepatogenesis in Zebrafish Requires Uhrf1. Genes. 12(7):
- Magnani, E., Macchi, F., Madakashira, B.P., Zhang, C., Alaydaroos, F., Sadler, K.C. (2021) uhrf1 and dnmt1 Loss Induces an Immune Response in Zebrafish Livers Due to Viral Mimicry by Transposable Elements. Frontiers in immunology. 12:627926
- Ganz, J., Melancon, E., Wilson, C., Amores, A., Batzel, P., Strader, M., Braasch, I., Diba, P., Kuhlman, J.A., Postlethwait, J.H., Eisen, J.S. (2019) Epigenetic factors Dnmt1 and Uhrf1 coordinate intestinal development. Developmental Biology. 455:473-484
- Rajshekar, S., Yao, J., Arnold, P.K., Payne, S.G., Zhang, Y., Bowman, T.V., Schmitz, R.J., Edwards, J.R., Goll, M. (2018) Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome. eLIFE. 7:
- Chernyavskaya, Y., Mudbhary, R., Tokarz, D., Jacob, V., Gopinath, S., Zhang, C., Sun, X., Wang, S., Magnani, E., Madakashira, B.P., Yoder, J.A., Hoshida, Y., Sadler, K.C. (2017) Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling. Development (Cambridge, England). 144(16):2925-2939
- Jacob, V., Chernyavskaya, Y., Chen, X., Tan, P.S., Kent, B., Hoshida, Y., Sadler, K.C. (2015) DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos. Development (Cambridge, England). 142(3):510-21
- Tittle, R.K., Sze, R., Ng, A., Nuckels, R.J., Swartz, M.E., Anderson, R.M., Bosch, J., Stainier, D.Y., Eberhart, J.K., and Gross, J.M. (2011) Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens. Developmental Biology. 350(1):50-63
- Anderson, R.M., Bosch, J.A., Goll, M.G., Hesselson, D., Dong, P.D., Shin, D., Chi, N.C., Shin, C.H., Schlegel, A., Halpern, M., and Stainier, D.Y. (2009) Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration. Developmental Biology. 334(1):213-223
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