Genomic Feature
hu3430
- ID
- ZDB-ALT-080806-3
- Name
- hu3430
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Hubrecht Institute
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 19: 629553 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A in Exon 2 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
AAAATGTTATGCAAATAAAATCAACTTAATAGTTAATTTAGTGTTAACCAGGAATTTTTTTTTACCGTAGCAGTTTACTATATATATATATTTTTTAATCAATTTTCATCATTACTGCCCTACTAAACATTGCACATCCATAACTGAGTTACGGCCAATGTTCTTCTATGTTTTCAGGATTTAAAAATATTTATGTATGTTTTTCTCTACAAATAAAAGAAATGTGTGTTATTTCAGCTCAGCACCCTGCCGGAGGTCTTGGCGTTCACTCTGAACCACATTAAACGTAAGAAACTGAGGAACGTCCTGGGCTTCGGTTATCAATGCAGCGACGTGACGACCAGTTCGGATCCCTTCCGTTTCCATGGTGACGTTTCGCAGACGGCTGCTTCCATCAGCACCAGCGAGGTCTGGAAGCGTATCAACCAGCGTCTGGGCACGGAGGTAACGCGGTACCTGCTGCAGGACTGTGCCGTTTTCACCACCGTCCCGCCATCGTG
T/A GTTCTGCAGGTGTGCGGAGAACCTGTTTACGACTTGCTGATGCCGCGCTCATGGTCTGGCTTTTTCCTCAGTAACTCAGATAATGAACGAATCAGCGGCGCGATGCGGAAATCCCCTGCTGTCCAGAAGACAGTCGCAATTTCCAAAAAGAGAACAAGAGATAACGAAAAATATATTTCGGTAAAGCGGCGGAGGGTAAAGGAAACTGTGAATAATAATAACGGAAATTACAGATCTCGGTGTTTTGCAATTTCTAAAAAGAGAGCGAGAGATAATGAAGAAAATATTTCGTTAAAGCGACGGAGGATGGAGGAAACTGACCAAGAAGCGAAAATACGTAATGAAAATCACGGATCTCAGAGTTTCACAATTTCTAAAAAGAGAGCGAGAGATAACGAAGAAAATATTTCGTTAAAGCGACAAAGGATGGAGGAAATTGACCAAGTAGCGAAAATACGTAACGAAAATCACGGATCTCAGAGTTGGAAACCAGCGGATCA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| terthu3430/hu3430 | Homozygous | ♀+/- ♂+/- | 5 figures  from 3 publications | ||
| terthu3430/hu3430 | Homozygous | Unknown | 2 figures from 2 publications | ||
| terthu3430/hu3430 | Homozygous | ♀-/- ♂-/- | 4 figures from Anchelin et al., 2013 | ||
| terthu3430/hu3430 (AB) | Homozygous | ♀+/- ♂+/- | 12 figures from 2 publications | Fig. 5 from Henriques et al., 2013 | |
| terthu3430/hu3430 (AB) | Homozygous | ♀-/- ♂-/- | Fig. S2 from Henriques et al., 2013 | ||
| terthu3430/hu3430 (TU) | Homozygous | ♀+/- ♂+/- | Figure 3 from Li et al., 2020 | ||
| terthu3430/+ | Heterozygous | ♀+/+ ♂-/- | 3 figures from 2 publications | ||
| terthu3430/+ | Heterozygous | ♀-/- ♂+/+ | Fig. S2 from Henriques et al., 2013 | ||
| terthu3430/+ | Heterozygous | Unknown | |||
| terthu3430/+ (AB) | Heterozygous | Unknown |
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Supplemental Information
- Genotyping protocol
- None
- Lopes-Bastos, B., Nabais, J., Ferreira, T., Allavena, G., El Maï, M., Bird, M., Targen, S., Tattini, L., Kang, D., Yue, J.X., Liti, G., Carvalho, T.G., Godinho Ferreira, M. (2024) The absence of telomerase leads to immune response and tumor regression in zebrafish melanoma. Cell Reports. 43:115035115035
- Şerifoğlu, N., Lopes-Bastos, B., Ferreira, M.G. (2024) Lack of telomerase reduces cancer incidence and increases lifespan of zebrafish tp53M214K mutants. Scientific Reports. 14:53825382
- Amin, A., Morello, M., Petrara, M.R., Rizzo, B., Argenton, F., De Rossi, A., Giunco, S. (2023) Short-Term TERT Inhibition Impairs Cellular Proliferation via a Telomere Length-Independent Mechanism and Can Be Exploited as a Potential Anticancer Approach. Cancers. 15(10):
- El Maï, M., Bird, M., Allouche, A., Targen, S., Şerifoğlu, N., Lopes-Bastos, B., Guigonis, J.M., Kang, D., Pourcher, T., Yue, J.X., Ferreira, M.G. (2023) Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish. Nature aging. 3(5):567-584
- Ellis, P.S., Martins, R.R., Thompson, E.J., Farhat, A., Renshaw, S.A., Henriques, C.M. (2022) A subset of gut leukocytes has telomerase-dependent "hyper-long" telomeres and require telomerase for function in zebrafish. Immunity & ageing : I & A. 19:31
- Martins, R.R., Zamzam, M., Tracey-White, D., Moosajee, M., Thummel, R., Henriques, C.M., MacDonald, R.B. (2022) Müller Glia maintain their regenerative potential despite degeneration in the aged zebrafish retina. Aging Cell. 21(4):e13597
- Espigares, F., Abad-Tortosa, D., Varela, S.A.M., Ferreira, M.G., Oliveira, R.F. (2021) Short telomeres drive pessimistic judgement bias in zebrafish. Biology letters. 17:20200745
- Lam, S., Hartmann, N., Benfeitas, R., Zhang, C., Arif, M., Turkez, H., Uhlén, M., Englert, C., Knight, R., Mardinoglu, A. (2021) Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases. Biomedicines. 9(10):
- Lee, L., Perez Oliva, A.B., Martinez-Balsalobre, E., Churikov, D., Peter, J., Rahmouni, D., Audoly, G., Azzoni, V., Audebert, S., Camoin, L., Mulero, V., Cayuela, M.L., Kulathu, Y., Geli, V., Lachaud, C. (2021) UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival. Science advances. 7:eabc7371
- El Maï, M., Marzullo, M., de Castro, I.P., Ferreira, M.G. (2020) Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish. eLIFE. 9:
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