Genomic Feature
t21384
- ID
- ZDB-ALT-070716-5
- Name
- t21384
- Synonyms
-
- HA327AA (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
-
European Zebrafish Resource Center (EZRC)
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Zebrafish International Resource Center (ZIRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 22: 16543397 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- A>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Lys>Stop at position 183 (1)
- Flanking Sequence
-
ATGCTTCCTTCCCTGTGATGTCGTAAACACCACATTGCTTTTCGGTTCCTCTGATCTGATTGGATGTTGTGAGCATGTTATTTTTGTCTGTAACTTGGTAACAACCAGTACAGCAACATCAAATTATCGTCTTGGAAGCAGACATTTATGTGGGTCCAACTTGTCATGGGCCAGTATAAGATTCTGATGGTATGATAACCTTAAACATACATATCAAGGTTTCACTGTATCACAGTATTGAGATTACTGCTCTAAAATATGTATAAAATAAAATATATATAAAATATATTTATGCACATTTTCAACATTAATGCACATCTTGGCTTTTCCATCAAACAATTTTTTTCATGCGCATATCCAAAATGCCCATAAAAATAGGTGGATGGAAACGTAGCTATTGTTGGGCGAACAATCAATTTAGTGTGGAAAATGTACTCTGACAATCTTGGAAAACTCTTTGCTGACAGTGTATTTGTTTTGTTTCTACAGGTTCGCAGCCC
A/T AAATTGTGCGACGGATTTTCACGAACAGTCGCGAGCGCTGGCGACAGCAGAATGTGAACGGTGCCTTCGCAGAGCTGCGCAAGCTCATCCCAACACACCCTCCTGACAAGAAACTCAGCAAGAACGAGATCCTGCGTCTGGCCATGAAGTACATCAACTTTCTGGCTAAGCTCCTCAACGACCAGGACGACATGGTCGGCGGTGAAGCTCCCGCCCGGGCCAATCGGGACAGCAGAGATGCAACTCTAGTGCGGGACGACCTCCTTCAGGAGATGCTAAGCCCCAACTCCAGCTGCGGGAGTCTGCTGGATGGGGATGCCAGCCCAGAGAGCTTTACTGAGGACCAGGACTCATCAGTGGAGTCCAGGCCCTCTGCAAGAGGACTACACCATTCCAGCCTACCGCTGGACGGAAATGCCCAGCGGTGACTGATTGGAGACACTGACAGACTAATTTCTCGGGCTGACAACTAGCGTATGTTCATGTTGTGTGCAAGCATA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| tal1t21384/t21384 | Homozygous | ♀+/- ♂+/- | 5 figures  from Andrzejczuk et al., 2018 | 9 figures from 3 publications | |
| tal1t21384/t21384 (TU) | Homozygous | ♀+/- ♂+/- | 3 figures from Bussmann et al., 2007 | 4 figures from Bussmann et al., 2007 | |
| tal1t21384/+ (AB) | Heterozygous | Unknown | |||
| tal1t21384/t21384; y1Tg | Complex | 3 figures from Bussmann et al., 2007 | |||
| tal1t21384/t21384; zf100Tg | Complex | 2 figures from Andrzejczuk et al., 2018 | Fig. 12 from Andrzejczuk et al., 2018 | ||
| tal1t21384/t21384; gata2aum27/um27 | Complex | Fig. 11 from Andrzejczuk et al., 2018 | |||
| tal1t21384/t21384; gata3sa0234/sa0234 | Complex | Fig. 10 from Andrzejczuk et al., 2018 | Fig. 10 from Andrzejczuk et al., 2018 | ||
| tal1t21384/t21384; gata3sa0234/sa0234; zf100Tg | Complex | Fig. 9 from Andrzejczuk et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Andrzejczuk, L.A., Banerjee, S., England, S.J., Voufo, C., Kamara, K., Lewis, K.E. (2018) Tal1, Gata2a, and Gata3 Have Distinct Functions in the Development of V2b and Cerebrospinal Fluid-Contacting KA Spinal Neurons. Frontiers in neuroscience. 12:170
- Hasegawa, T., Nakajima, T., Ishida, T., Kudo, A., Kawakami, A. (2015) A diffusible signal derived from hematopoietic cells supports the survival and proliferation of regenerative cells during zebrafish fin fold regeneration. Developmental Biology. 399(1):80-90
- Cooney, J.D., Hildick-Smith, G.J., Shafizadeh, E., McBride, P.F., Carroll, K.J., Anderson, H., Shaw, G.C., Tamplin, O.J., Branco, D.S., Dalton, A.J., Shah, D.I., Wong, C., Gallagher, P.G., Zon, L.I., North, T.E., and Paw, B.H. (2013) Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis. Developmental Biology. 373(2):431-441
- Paik, E.J., and Zon, L.I. (2010) Hematopoietic development in the zebrafish. The International journal of developmental biology. 54(6-7):1127-1137
- Herpers, R., van de Kamp, E., Duckers, H.J., and Schulte-Merker, S. (2008) Redundant Roles for Sox7 and Sox18 in Arteriovenous Specification in Zebrafish. Circulation research. 102(1):12-15
- Bussmann, J., Bakkers, J., and Schulte-Merker, S. (2007) Early Endocardial Morphogenesis Requires Scl/Tal1. PLoS Genetics. 3(8):e140
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