Genomic Feature
st60
- ID
- ZDB-ALT-070601-1
- Name
- st60
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Talbot Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 21: 13188928 (GRCz11) (1) Details
- Nucleotide change
- G/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Glu>Stop at position 1491 (1)
- Flanking Sequence
-
GACATCAGGTGCGTAAAAACACCTATACAGCATTGCAGAAGAGTTTTCCTTAACATCTTTTTAATACACTGACATGTTCACATTGTGTAGGAACACCGCACTGAGATCGACGCTCGTGCAGGAACCTTCCTGGCTTTTGAGCAGTTTGGACAGCAGCTGCTCGCTCGTGGGCATTACGCAAGCCCTGAGATCAAACAGAAGCTGGAGGCTCTTGACCGGGAGCGTGCTGACCTGGAGAAGGCCTGGGTTCAGCGCAGGATGATGCTGGACCAGTGCCTGGAGCTGCAGGTCAACAGAAACCCTTGAGTACATCTCATACAACTCTTGGATGTTTGAAGATGTTTCCCTCAAATGATGCCATGTTCCTTTTTTGTCTCCCTCAGTTGTTTAACCGTGACTGTGAGCAGGCTGAGAACTGGATGGCTGCCCGCGAAGCCTTCTTAGCCAGCGATGACAAGGGAGATTCTCTGGACAGTGTGGAGGCGCTCATTAAGAAACAC
G/T AGGACTTTGATAAGGCTATCAATGTGCAGGTCAGACGATCATATGATCAAGTTCTAAATCTTTGAATTGTTTGAATGTTTTTATTCAGAACTAATCAATTCAATTCATGAATTCTCACAGGAAGAAAAGATTGCTGCACTGCAGTCTTTTGCTGACCAGCTCATCAGCGCTGACCACTATGCCAAGCCTGAGATCTTCAAACGACGCAGTGAGGTCTTGGACAGGTCAGTGTTCTCTTTTTTTTCCTGCTTAGATTGAGTAAATAGGTTGACATTTGGGGTTTGAGCTTATGTTTGAACTTACATTTTAAGCCAAGTTAAGGTTTGAGTTAATGTTTGTGAATACGTTTGGGTTGATGTTTGAGCTCACGTTCTAGGCAAAAGTAAGATTTGGGGTTAACGTTTGACGTTAACATTTTTGATCTTACGTTAGAGCAACGTAGATCTTGCCTTGATCTTACCTTAACATGTTTGATCTTACGTTAGAGCTTACATTTTAGG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| sptan1st60/st60 | Homozygous | ♀+/- ♂+/- | 5 figures  from 2 publications | 4 figures from Voas et al., 2007 | |
| sptan1st60/+ | Heterozygous | ♀+/- ♂+/- | 2 figures from Susuki et al., 2011 | ||
| sptan1st60/+ (AB) | Heterozygous | Unknown |
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Supplemental Information
- Genotyping protocol
- st60.pdf
- Susuki, K., Raphael, A.R., Ogawa, Y., Stankewich, M.C., Peles, E., Talbot, W.S., and Rasband, M.N. (2011) Schwann cell spectrins modulate peripheral nerve myelination. Proceedings of the National Academy of Sciences of the United States of America. 108(19):8009-8014
- Voas, M.G., Lyons, D.A., Naylor, S.G., Arana, N., Rasband, M.N., and Talbot, W.S. (2007) alphaII-Spectrin Is Essential for Assembly of the Nodes of Ranvier in Myelinated Axons. Current biology : CB. 17(6):562-568
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