Genomic Feature
hi2393Tg
- ID
- ZDB-ALT-040930-12
- Name
- hi2393Tg
- Synonyms
-
- hi2393 (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion (1)
- Protocol
- embryos treated with DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the plus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 14: 9085240 - 9085241 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Intron 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| polr1dhi2393Tg/hi2393Tg | Homozygous | Unknown | text only from Amsterdam et al., 2004 | ||
| polr1dhi2393Tg/hi2393Tg | Homozygous | ♀+/- ♂+/- | 8 figures  from 2 publications | 2 figures from Noack Watt et al., 2016 | |
| polr1dhi2393Tg/+ (AB) | Heterozygous | Unknown | |||
| polr1dhi2393Tg/+ (AB/TU) | Heterozygous | Unknown | |||
| polr1dhi2393Tg | Unknown | Unknown | Fig. for (hi2393) from Phenotype Annotation (1994-2006) | ||
| polr1dhi2393Tg/hi2393Tg; ir937Tg | Complex | Fig. S4 from Noack Watt et al., 2016 | |||
| polr1dhi2393Tg/hi2393Tg; y1Tg | Complex | Fig. 5 from Noack Watt et al., 2016 | |||
| tp53zdf1/+; polr1dhi2393Tg/hi2393Tg | Complex | Fig. 8 from Noack Watt et al., 2016 | |||
| tp53zdf1/zdf1; polr1dhi2393Tg/hi2393Tg | Complex | 3 figures from Noack Watt et al., 2016 |
1 - 9 of 9
Show
Supplemental Information
- Genotyping protocol
- None
- Calo, E., Gu, B., Bowen, M.E., Aryan, F., Zalc, A., Liang, J., Flynn, R.A., Swigut, T., Chang, H.Y., Attardi, L.D., Wysocka, J. (2018) Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Nature. 554:112-117
- Noack Watt, K.E., Achilleos, A., Neben, C.L., Merrill, A.E., Trainor, P.A. (2016) The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome. PLoS Genetics. 12:e1006187
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
1 - 3 of 3
Show