Genomic Feature
hi2216Tg
- ID
- ZDB-ALT-040924-2
- Name
- hi2216Tg
- Synonyms
-
- hi2216 (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion (1)
- Protocol
- embryos treated with DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the minus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 8: 46385717 - 46385718 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Intron 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| qars1hi2216Tg/hi2216Tg | Homozygous | Unknown | text only from Amsterdam et al., 2004 | ||
| qars1hi2216Tg/hi2216Tg | Homozygous | ♀+/- ♂+/- | Fig. 5 from Zhang et al., 2014 | ||
| qars1hi2216Tg/+ (AB) | Heterozygous | Unknown | |||
| qars1hi2216Tg/+ (AB/TU) | Heterozygous | Unknown | |||
| qars1hi2216Tg | Unknown | Unknown | Fig. for (hi2216)  from Phenotype Annotation (1994-2006) |
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Supplemental Information
- Genotyping protocol
- None
- Zhang, X., Ling, J., Barcia, G., Jing, L., Wu, J., Barry, B.J., Mochida, G.H., Hill, R.S., Weimer, J.M., Stein, Q., Poduri, A., Partlow, J.N., Ville, D., Dulac, O., Yu, T.W., Lam, A.T., Servattalab, S., Rodriguez, J., Boddaert, N., Munnich, A., Colleaux, L., Zon, L.I., Söll, D., Walsh, C.A., Nabbout, R. (2014) Mutations in QARS, Encoding Glutaminyl-tRNA Synthetase, Cause Progressive Microcephaly, Cerebral-Cerebellar Atrophy, and Intractable Seizures. American journal of human genetics. 94:547-58
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
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