Genomic Feature
hi1520Tg
- ID
- ZDB-ALT-040728-2
- Name
- hi1520Tg
- Synonyms
-
- hi1520 (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion (1)
- Protocol
- embryos treated with DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the minus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 14: 35370576 - 35370577 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Intron 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| clint1ahi1520Tg/hi1520Tg | Homozygous | ♀+/- ♂+/- | 3 figures  from 3 publications | ||
| clint1ahi1520Tg/hi1520Tg (AB) | Homozygous | ♀+/- ♂+/- | 5 figures from Dodd et al., 2009 | 4 figures from Dodd et al., 2009 | |
| clint1ahi1520Tg/+ | Heterozygous | Unknown | |||
| clint1ahi1520Tg/+ (AB) | Heterozygous | ♀+/- ♂+/- | Fig. 1 from Dodd et al., 2009 | ||
| clint1ahi1520Tg/+ (AB/TU) | Heterozygous | Unknown | |||
| clint1ahi1520Tg | Unknown | Unknown | Fig. for (hi1520) from Phenotype Annotation (1994-2006) | ||
| clint1ahi1520Tg/hi1520Tg; uwm1Tg (AB) | Complex | Fig. 3 from Dodd et al., 2009 | |||
| clint1ahi1520Tg/hi1520Tg + MO1-st14a | Complex | Fig 1 from Hatzold et al., 2023 |
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Supplemental Information
- Genotyping protocol
- hi1520tg.pdf
- Hatzold, J., Nett, V., Brantsch, S., Zhang, J.L., Armistead, J., Wessendorf, H., Stephens, R., Humbert, P.O., Iden, S., Hammerschmidt, M. (2023) Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects. PLoS Genetics. 19:e1010873e1010873
- LeBert, D.C., Squirrell, J.M., Rindy, J., Broadbridge, E., Lui, Y., Zakrzewska, A., Eliceiri, K.W., Meijer, A.H., Huttenlocher, A. (2015) Matrix metalloproteinase 9 modulates collagen matrices and wound repair. Development (Cambridge, England). 142(12):2136-46
- Danilova, N., Kumagai, A., and Lin, J. (2010) p53 Upregulation Is a Frequent Response to Deficiency of Cell-Essential Genes. PLoS One. 5(12):e15938
- Dodd, M.E., Hatzold, J., Mathias, J.R., Walters, K.B., Bennin, D.A., Rhodes, J., Kanki, J.P., Look, A.T., Hammerschmidt, M., and Huttenlocher, A. (2009) The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish. Development (Cambridge, England). 136(15):2591-2600
- Kishi, S., Bayliss, P.E., Uchiyama, J., Koshimizu, E., Qi, J., Nanjappa, P., Imamura, S., Islam, A., Neuberg, D., Amsterdam, A., and Roberts, T.M. (2008) The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genetics. 4(8):e1000152
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
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