Genomic Feature
hi2582Tg
- ID
- ZDB-ALT-040622-16
- Name
- hi2582Tg
- Synonyms
-
- hi2582 (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion
- Protocol
- DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the minus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 21: 26072330 - 26072331 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Intron 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| rpl23ahi2582Tg/hi2582Tg | Homozygous | ♀+/- ♂+/- | Fig. S1 from Antunes et al., 2015 | ||
| rpl23ahi2582Tg/+ | Heterozygous | Unknown | |||
| rpl23ahi2582Tg/+ (AB) | Heterozygous | Unknown | |||
| rpl23ahi2582Tg/+ (AB/TU) | Heterozygous | Unknown | Fig. 3  from Lai et al., 2009 | ||
| rpl23ahi2582Tg | Unknown | Unknown | |||
| rpl23ahi2582Tg/hi2582Tg; jh1Tg; jh2Tg | Complex | Fig. 2 from Provost et al., 2013 | |||
| rpl23ahi2582Tg/+; jh1Tg; jh2Tg | Complex | Fig. 2 from Provost et al., 2013 | |||
| rpl23ahi2582Tg/+; jh16Tg; mk202Tg | Complex | 3 figures from Provost et al., 2014 | Fig. 1 from Provost et al., 2014 | ||
| rpl23ahi2582Tg/hi2582Tg; jh1Tg; jh2Tg + MO4-tp53 | Complex | Fig. 4 from Provost et al., 2013 | |||
| rpl23ahi2582Tg/+; jh1Tg; jh2Tg + MO4-tp53 | Complex | Fig. 4 from Provost et al., 2013 |
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Supplemental Information
- Genotyping protocol
- hi2582tg.pdf
- Antunes, A.T., Goos, Y.J., Pereboom, T.C., Hermkens, D., Wlodarski, M.W., Da Costa, L., MacInnes, A.W. (2015) Ribosomal Protein Mutations Result in Constitutive p53 Protein Degradation through Impairment of the AKT Pathway. PLoS Genetics. 11:e1005326
- Provost, E., Bailey, J.M., Aldrugh, S., Liu, S., Iacobuzio-Donahue, C., Leach, S.D. (2014) The Tumor Suppressor rpl36 Restrains KRAS(G12V)-Induced Pancreatic Cancer. Zebrafish. 11(6):551-9
- Provost, E., Weier, C.A., and Leach, S.D. (2013) Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development. Zebrafish. 10(2):161-169
- Lai, K., Amsterdam, A., Farrington, S., Bronson, R.T., Hopkins, N., and Lees, J.A. (2009) Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(1):76-85
- Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S., Bronson, R.T., Lees, J.A., and Hopkins, N. (2004) Many ribosomal protein genes are cancer genes in zebrafish. PLoS Biology. 2(5):E139
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