Knl1/Spc105 complex

Term ID

GO:0180019

Synonyms

• KNL-1 complex
• KNL1 complex
• Spc105 complex
• Spc105p/Kre28p complex

Definition

A kinetochore subcomplex that binds to centromeric chromatin and forms part of the outer kinetochore. It is involved in kinetochore-microtubule binding, recruiting microtubule binding outer kinetochore subunits. It is essential for kinetochore binding by components of the spindle assembly checkpoint. In humans, budding and fission yeast, it consists of KNL1/ZWINT, Spc105p/Kre28p and Spc7/Sos1, members of the Panther PTHR28260 and PTHR37329 families, respectively. (2)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO