transcription pausing by RNA polymerase II

Term ID

GO:0160239

Synonyms

• promoter proximal pausing by RNA polymerase II

Definition

A transcription halt following transcription initiation but prior to elongation, during which RNA polymerase II pauses approximately 20-60 nucleotides downstream of the transcriptional start site before proceeding into productive elongation. Transcription pausing starts following phosphorylation of the C-terminal domain (CTD) of RNA polymerase II subunit POLR2A at Ser-5 and stops following phosphorylation of POLR2A by the P-TEFb complex. (2)

References

Ontology

GO: Biological Process    QuickGO    AmiGO