2-oxoglutarate decarboxylation to succinyl-CoA

Term ID

GO:0120551

Synonyms

• 2-ketoglutarate dehydrogenase system
• 2-oxoglutarate dehydrogenase system
• 2alpha-ketoglutarate dehydrogenase system

Definition

The chemical reactions and pathways resulting in the formation of succinyl-CoA from 2-oxoglutarate. In most organisms, this pathway is part of the TCA cycle and comprises a series of three reactions carried out by a multisubunit complex called the '2-oxoglutarate dehydrogenase complex', even though 2-oxoglutarate dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: 2-oxoglutarate + coenzyme A + NAD+ -> succinyl-CoA + CO2 + NADH.

References

• MetaCyc:PWY-5084

Ontology

GO: Biological Process    QuickGO    AmiGO