Search Ontology:
GO: Biological Process

hypoxia-inducible factor-1alpha signaling pathway

Term ID
GO:0097411
Synonyms
  • HIF1alpha pathway
  • hypoxia-inducible factor signaling
  • hypoxia-inducible factor-1alpha signalling pathway
Definition
The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia. (2)
References
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
Phenotype
Phenotype caused by Genes
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