NAD+ nucleosidase activity, cyclic ADP-ribose generating

Term ID

GO:0061809

Synonyms

• ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
• NAD hydrolase
• NAD(+) nucleosidase
• NADase
• nicotinamide adenine dinucleotide nucleosidase

Definition

Catalysis of the reaction: NAD+ + H2O = ADP-D-ribose + nicotinamide + H+, in a two step reaction: first an ADP-ribosyl cyclase reaction to synthesise cyclic ADP-ribose, followed by a cyclic ADP-ribose hydrolase reaction to generate (linear) ADP-ribose. (2)

References

• EC:3.2.2.6
• MetaCyc:NADNUCLEOSID-RXN
• Reactome:R-HSA-8870346
• Reactome:R-HSA-8938076
• Reactome:R-HSA-9637699

Ontology

GO: Molecular Function    QuickGO    AmiGO