T-helper 1 cell differentiation

Term ID

GO:0045063

Synonyms

T-helper 1 cell development

Definition

The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.

References

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

is part of: T-helper 1 type immune response

T-helper 1 type immune response Show first 5 Terms
has parts: T-helper 1 cell lineage commitment

T-helper 1 cell lineage commitment Show first 5 Terms
is a type of: T-helper cell differentiation

T-helper cell differentiation Show first 5 Terms
negatively regulated by: negative regulation of T-helper 1 cell differentiation

negative regulation of T-helper 1 cell differentiation Show first 5 Terms
positively regulated by: positive regulation of T-helper 1 cell differentiation

positive regulation of T-helper 1 cell differentiation Show first 5 Terms
regulated by: regulation of T-helper 1 cell differentiation

regulation of T-helper 1 cell differentiation Show first 5 Terms

Phenotype

Phenotype caused by Genes