negative cofactor 2 complex

Term ID

GO:0017054

Synonyms

Definition

A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini. 15574413

References

Ontology

GO: Cellular Component    QuickGO    AmiGO