pyruvate decarboxylation to acetyl-CoA

Term ID

GO:0006086

Synonyms

• acetyl-CoA anabolism from pyruvate
• acetyl-CoA biosynthetic process from pyruvate
• acetyl-CoA formation from pyruvate
• acetyl-CoA synthesis from pyruvate
• oxidative decarboxylation of pyruvate
• pyruvate decarboxylation
• pyruvate dehydrogenase pathway

Definition

The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: pyruvate + coenzyme A + NAD+ -> acetyl-CoA + CO2 + NADH.

References

• MetaCyc:PYRUVDEHYD-PWY
• Reactome:R-HSA-9861559

Ontology

GO: Biological Process    QuickGO    AmiGO