Search Ontology:
GO: Molecular Function

guanyl-nucleotide exchange factor activity

Term ID
GO:0005085
Synonyms
  • ARF guanyl-nucleotide exchange factor activity
  • cAMP-dependent guanyl-nucleotide exchange factor activity
  • GDP-dissociation stimulator activity
  • GDS
  • GEF
  • GNRP
  • guanyl-nucleotide release factor activity
  • guanyl-nucleotide releasing factor
  • Rab guanyl-nucleotide exchange factor activity
  • Rac guanyl-nucleotide exchange factor activity
  • Ral guanyl-nucleotide exchange factor activity
  • Ran guanyl-nucleotide exchange factor activity
  • Rap guanyl-nucleotide exchange factor activity
  • Ras guanyl-nucleotide exchange factor activity
  • Rho guanine nucleotide exchange factor
  • Rho guanyl-nucleotide exchange factor activity
  • RhoGEF
  • Sar guanyl-nucleotide exchange factor activity
(all 18)
Definition
Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. (2)
References
  • Reactome:R-HSA-109807
  • Reactome:R-HSA-109817
  • Reactome:R-HSA-114544
  • Reactome:R-HSA-1168636
  • Reactome:R-HSA-1225951
  • Reactome:R-HSA-1225957
  • Reactome:R-HSA-1250383
  • Reactome:R-HSA-1250463
  • Reactome:R-HSA-1250498
  • Reactome:R-HSA-1306972
  • Reactome:R-HSA-1433415
  • Reactome:R-HSA-1433471
  • Reactome:R-HSA-156913
  • Reactome:R-HSA-169904
  • Reactome:R-HSA-170979
  • Reactome:R-HSA-171026
  • Reactome:R-HSA-177938
  • Reactome:R-HSA-177945
  • Reactome:R-HSA-180687
  • Reactome:R-HSA-186834
  • Reactome:R-HSA-187746
  • Reactome:R-HSA-194518
  • Reactome:R-HSA-2029445
  • Reactome:R-HSA-2029451
  • Reactome:R-HSA-2029467
  • Reactome:R-HSA-203977
  • Reactome:R-HSA-205039
  • Reactome:R-HSA-210977
  • Reactome:R-HSA-2179407
  • Reactome:R-HSA-2424476
  • Reactome:R-HSA-2424477
  • Reactome:R-HSA-2485180
  • Reactome:R-HSA-2730840
  • Reactome:R-HSA-350769
  • Reactome:R-HSA-354173
  • Reactome:R-HSA-379044
  • Reactome:R-HSA-379048
  • Reactome:R-HSA-380073
  • Reactome:R-HSA-389348
  • Reactome:R-HSA-389350
  • Reactome:R-HSA-392054
  • Reactome:R-HSA-392195
  • Reactome:R-HSA-3928592
  • Reactome:R-HSA-3928612
  • Reactome:R-HSA-3928628
  • Reactome:R-HSA-3928632
  • Reactome:R-HSA-3928633
  • Reactome:R-HSA-3928642
  • Reactome:R-HSA-3928651
  • Reactome:R-HSA-392870
  • Reactome:R-HSA-3965444
  • Reactome:R-HSA-399938
  • Reactome:R-HSA-399995
  • Reactome:R-HSA-400092
  • Reactome:R-HSA-4093336
  • Reactome:R-HSA-416530
  • Reactome:R-HSA-416588
  • Reactome:R-HSA-418579
  • Reactome:R-HSA-418850
  • Reactome:R-HSA-418856
  • Reactome:R-HSA-419166
  • Reactome:R-HSA-420883
  • Reactome:R-HSA-428535
  • Reactome:R-HSA-428750
  • Reactome:R-HSA-428917
  • Reactome:R-HSA-442273
  • Reactome:R-HSA-442291
  • Reactome:R-HSA-442314
  • Reactome:R-HSA-442732
  • Reactome:R-HSA-445064
  • Reactome:R-HSA-5218829
  • Reactome:R-HSA-5218839
  • Reactome:R-HSA-5218850
  • Reactome:R-HSA-5617816
  • Reactome:R-HSA-5623508
  • Reactome:R-HSA-5623521
  • Reactome:R-HSA-5637806
  • Reactome:R-HSA-5637808
  • Reactome:R-HSA-5654392
  • Reactome:R-HSA-5654402
  • Reactome:R-HSA-5654413
  • Reactome:R-HSA-5654426
  • Reactome:R-HSA-5654600
  • Reactome:R-HSA-5654618
  • Reactome:R-HSA-5654647
  • Reactome:R-HSA-5654663
  • Reactome:R-HSA-5655241
  • Reactome:R-HSA-5655277
  • Reactome:R-HSA-5655326
  • Reactome:R-HSA-5655347
  • Reactome:R-HSA-5672965
  • Reactome:R-HSA-5686071
  • Reactome:R-HSA-5686318
  • Reactome:R-HSA-5694409
  • Reactome:R-HSA-6807868
  • Reactome:R-HSA-6811414
  • Reactome:R-HSA-6811418
  • Reactome:R-HSA-6811429
  • Reactome:R-HSA-749453
  • Reactome:R-HSA-751029
  • Reactome:R-HSA-825631
  • Reactome:R-HSA-8848618
  • Reactome:R-HSA-8850041
  • Reactome:R-HSA-8851827
  • Reactome:R-HSA-8851877
  • Reactome:R-HSA-8851899
  • Reactome:R-HSA-8875318
  • Reactome:R-HSA-8875320
  • Reactome:R-HSA-8875568
  • Reactome:R-HSA-8875591
  • Reactome:R-HSA-8876188
  • Reactome:R-HSA-8876190
  • Reactome:R-HSA-8876191
  • Reactome:R-HSA-8876193
  • Reactome:R-HSA-8876454
  • Reactome:R-HSA-8876615
  • Reactome:R-HSA-8876616
  • Reactome:R-HSA-8876837
  • Reactome:R-HSA-8877308
  • Reactome:R-HSA-8877311
  • Reactome:R-HSA-8877451
  • Reactome:R-HSA-8877475
  • Reactome:R-HSA-8877612
  • Reactome:R-HSA-8877760
  • Reactome:R-HSA-8877813
  • Reactome:R-HSA-8877998
  • Reactome:R-HSA-8964604
  • Reactome:R-HSA-8980691
  • Reactome:R-HSA-8982637
  • Reactome:R-HSA-8982640
  • Reactome:R-HSA-9013023
  • Reactome:R-HSA-9013109
  • Reactome:R-HSA-9013143
  • Reactome:R-HSA-9013159
  • Reactome:R-HSA-9013435
  • Reactome:R-HSA-9014296
  • Reactome:R-HSA-9014433
  • Reactome:R-HSA-9017491
  • Reactome:R-HSA-9018747
  • Reactome:R-HSA-9018768
  • Reactome:R-HSA-9018804
  • Reactome:R-HSA-9018817
  • Reactome:R-HSA-9018825
  • Reactome:R-HSA-9026891
  • Reactome:R-HSA-9029158
  • Reactome:R-HSA-9032067
  • Reactome:R-HSA-9032798
  • Reactome:R-HSA-9033292
  • Reactome:R-HSA-9036301
  • Reactome:R-HSA-939265
  • Reactome:R-HSA-9607304
  • Reactome:R-HSA-9619803
  • Reactome:R-HSA-9624845
  • Reactome:R-HSA-9634418
  • Reactome:R-HSA-9639286
  • Reactome:R-HSA-9640167
  • Reactome:R-HSA-9660824
  • Reactome:R-HSA-9664991
  • Reactome:R-HSA-9665009
  • Reactome:R-HSA-9665404
  • Reactome:R-HSA-9665408
  • Reactome:R-HSA-9665700
  • Reactome:R-HSA-9665707
  • Reactome:R-HSA-9666428
  • Reactome:R-HSA-9666430
  • Reactome:R-HSA-9670436
  • Reactome:R-HSA-9672163
  • Reactome:R-HSA-9672170
  • Reactome:R-HSA-9680385
  • Reactome:R-HSA-9693111
  • Reactome:R-HSA-9695853
  • Reactome:R-HSA-9703441
  • Reactome:R-HSA-9751201
(all 173)
Ontology
GO: Molecular Function    QuickGO    AmiGO
Relationships
is a type of
negatively regulated by
negatively regulates
positively regulated by
positively regulates
regulated by
Phenotype
Phenotype caused by Genes
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.