oxoglutarate dehydrogenase (succinyl-transferring) activity

Term ID

GO:0004591

Synonyms

• 2-ketoglutarate dehydrogenase activity
• 2-oxoglutarate dehydrogenase activity
• 2-oxoglutarate: lipoate oxidoreductase activity
• 2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)
• 2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity
• AKGDH activity
• alpha-ketoglutarate dehydrogenase activity
• alpha-ketoglutaric acid dehydrogenase activity
• alpha-ketoglutaric dehydrogenase activity
• alpha-oxoglutarate dehydrogenase activity
• ketoglutaric dehydrogenase activity
• OGDC activity
• oxoglutarate decarboxylase activity
• oxoglutarate dehydrogenase (lipoamide) activity
• oxoglutarate dehydrogenase activity

Definition

Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H+ = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2.

References

• EC:1.2.4.2
• MetaCyc:2OXOGLUTDECARB-RXN
• RHEA:12188
• Reactome:R-HSA-71401

Ontology

GO: Molecular Function    QuickGO    AmiGO