hydroxymethylbilane synthase activity

Term ID

GO:0004418

Synonyms

• (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity
• (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
• HMB-synthase activity
• porphobilinogen ammonia-lyase (polymerizing)
• porphobilinogen deaminase activity
• porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
• pre-uroporphyrinogen synthase activity
• uroporphyrinogen I synthase activity
• uroporphyrinogen I synthetase activity
• uroporphyrinogen synthase activity
• uroporphyrinogen synthetase activity

(all 11)

Definition

Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4. 2.5.1.61

References

• EC:2.5.1.61
• KEGG_REACTION:R00084
• MetaCyc:OHMETHYLBILANESYN-RXN
• RHEA:13185
• Reactome:R-HSA-189406

(all 5)

Ontology

GO: Molecular Function    QuickGO    AmiGO