GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity

Term ID

GO:0004377

Synonyms

• GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity
• GDP-mannose-oligosaccharide-lipid mannosyltransferase activity
• GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity
• glycolipid 2-alpha-mannosyltransferase activity
• guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity
• oligosaccharide-lipid mannosyltransferase activity

Definition

Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. 2.4.1.131

References

• EC:2.4.1.131
• MetaCyc:RXN-5464
• RHEA:29523

Ontology

GO: Molecular Function    QuickGO    AmiGO